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Homo sapiens (human): 135
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Entry
135 CDS
T01001
Symbol
ADORA2A, A2aR, ADORA2, RDC8
Name
(RefSeq) adenosine A2a receptor
KO
K04266
adenosine receptor A2a
Organism
hsa
Homo sapiens (human)
Pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04024
cAMP signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04270
Vascular smooth muscle contraction
hsa05012
Parkinson disease
hsa05034
Alcoholism
Drug target
Adenosine (
DG00243
):
D00045
<JP/US>
D02300
<JP>
D02769
D08646
D08647
Apadenoson:
D03212
Binodenoson:
D03120
Caffeine (
DG00974
):
D00528
<JP>
D01453
<JP>
D07603
<US>
Choline theophyllinate:
D02017
Ciforadenant:
D11547
Doxofylline:
D03898
Enprofylline:
D04006
Etrumadenant:
D12369
Evodenoson:
D10362
Inupadenant (
DG03145
):
D11978
D11979
Istradefylline:
D04641
<JP/US>
Preladenant:
D09717
Proxyphylline:
D01771
<JP>
Regadenoson (
DG03262
):
D05711
<US>
D12568
<US>
Sonedenoson:
D09003
Tozadenant:
D10174
Vipadenant:
D09991
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
135 (ADORA2A)
04020 Calcium signaling pathway
135 (ADORA2A)
04024 cAMP signaling pathway
135 (ADORA2A)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
135 (ADORA2A)
09150 Organismal Systems
09153 Circulatory system
04270 Vascular smooth muscle contraction
135 (ADORA2A)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
135 (ADORA2A)
09165 Substance dependence
05034 Alcoholism
135 (ADORA2A)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
135 (ADORA2A)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Base and nucleoside
Adenosine
135 (ADORA2A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
7tm_1
7TM_GPCR_Srsx
7tm_4
7TM_GPCR_Srx
GPR_Gpa2_C
Motif
Other DBs
NCBI-GeneID:
135
NCBI-ProteinID:
NP_000666
OMIM:
102776
HGNC:
263
Ensembl:
ENSG00000128271
UniProt:
P29274
X5DNB4
B3KVQ4
Structure
PDB
LinkDB
All DBs
Position
22:24423597..24442357
Genome browser
AA seq
412 aa
AA seq
DB search
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
NT seq
1239 nt
NT seq
+upstream
nt +downstream
nt
atgcccatcatgggctcctcggtgtacatcacggtggagctggccattgctgtgctggcc
atcctgggcaatgtgctggtgtgctgggccgtgtggctcaacagcaacctgcagaacgtc
accaactactttgtggtgtcactggcggcggccgacatcgcagtgggtgtgctcgccatc
ccctttgccatcaccatcagcaccgggttctgcgctgcctgccacggctgcctcttcatt
gcctgcttcgtcctggtcctcacgcagagctccatcttcagtctcctggccatcgccatt
gaccgctacattgccatccgcatcccgctccggtacaatggcttggtgaccggcacgagg
gctaagggcatcattgccatctgctgggtgctgtcgtttgccatcggcctgactcccatg
ctaggttggaacaactgcggtcagccaaaggagggcaagaaccactcccagggctgcggg
gagggccaagtggcctgtctctttgaggatgtggtccccatgaactacatggtgtacttc
aacttctttgcctgtgtgctggtgcccctgctgctcatgctgggtgtctatttgcggatc
ttcctggcggcgcgacgacagctgaagcagatggagagccagcctctgccgggggagcgg
gcacggtccacactgcagaaggaggtccatgctgccaagtcactggccatcattgtgggg
ctctttgccctctgctggctgcccctacacatcatcaactgcttcactttcttctgcccc
gactgcagccacgcccctctctggctcatgtacctggccatcgtcctctcccacaccaat
tcggttgtgaatcccttcatctacgcctaccgtatccgcgagttccgccagaccttccgc
aagatcattcgcagccacgtcctgaggcagcaagaacctttcaaggcagctggcaccagt
gcccgggtcttggcagctcatggcagtgacggagagcaggtcagcctccgtctcaacggc
cacccgccaggagtgtgggccaacggcagtgctccccaccctgagcggaggcccaatggc
tatgccctggggctggtgagtggagggagtgcccaagagtcccaggggaacacgggcctc
ccagacgtggagctccttagccatgagctcaagggagtgtgcccagagccccctggccta
gatgaccccctggcccaggatggagcaggagtgtcctga
DBGET
integrated database retrieval system