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Homo sapiens (human): 5146
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Entry
5146 CDS
T01001
Symbol
PDE6C, ACHM5, COD4, PDEA2
Name
(RefSeq) phosphodiesterase 6C
KO
K13757
cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:
3.1.4.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
Disease
H00481
Cone-rod dystrophy and cone dystrophy
H00971
Achromatopsia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5146 (PDE6C)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
5146 (PDE6C)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
GAF
GAF_2
GAF_3
Motif
Other DBs
NCBI-GeneID:
5146
NCBI-ProteinID:
NP_006195
OMIM:
600827
HGNC:
8787
Ensembl:
ENSG00000095464
UniProt:
P51160
Structure
PDB
LinkDB
All DBs
Position
10:93612537..93666010
Genome browser
AA seq
858 aa
AA seq
DB search
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
NT seq
2577 nt
NT seq
+upstream
nt +downstream
nt
atgggtgagatcaaccaagttgccgtggagaaatacctggaggagaaccctcagtttgcc
aaggagtactttgacaggaagttgcgggtggaggtgctgggagaaatcttcaagaacagc
caggtgccagtccagtccagcatgtccttctctgagctgacccaggtggaggagtcagcc
ctgtgcttggagctgctgtggaccgtgcaggaggaggggggcaccccagagcagggggtt
cacagggccctgcagaggctggcccacctgctccaggctgaccgctgcagcatgttcctg
tgccggtcccggaacggcatacctgaggtggcctctaggttgctggatgtcacccccacc
tccaagtttgaggacaacctggtgggccctgacaaagaagttgtgtttccattggacatt
gggatagtgggttgggctgctcacacgaagaaaactcataatgtcccagatgtgaaaaag
aacagccatttttctgacttcatggacaagcaaactgggtatgtcactaagaacctgctg
gcaaccccgatcgtggtgggcaaggaggttcttgctgtgatcatggcagttaacaaagta
aatgcatctgaattttccaaacaggatgaagaggtcttttccaaatacctcaactttgtg
tctatcatcctaaggcttcatcacaccagctacatgtacaatattgaatcccgaagaagc
cagatccttatgtggtcagccaataaagtatttgaagaactcacagatgttgagcgacag
tttcacaaagcgctctacacggttagatcatatctgaactgtgaacgatactccattgga
ctgctggacatgaccaaggagaaggaattctacgatgaatggccaatcaagcttggagaa
gtagagccttataaaggtccaaagacacctgatggcagggaagtcaacttttataaaatc
attgattacattttacatggaaaagaagagatcaaagtgattccgacgcctcctgcagac
cactggacactcattagtgggttgccaacatatgttgctgaaaatggatttatctgtaac
atgatgaatgcccctgcggatgaatacttcacatttcagaaaggacctgtagacgaaact
ggttgggtcattaagaatgttttgtccctgcctattgtcaacaagaaagaagatattgtg
ggagtggctacattttacaacaggaaggatggaaaacctttcgatgagcatgatgaatac
attaccgagactctcacacaatttcttggatggtctcttttaaatactgacacctacgat
aagatgaataagctagaaaacagaaaggacattgctcaggaaatgctcatgaaccaaacc
aaagccactcctgaagaaattaagtccattttgaaatttcaagagaagttaaatgttgat
gtaattgacgactgtgaagaaaaacaacttgttgcaattttgaaagaggacttgccagac
ccacgctcagcagaactgtacgaattccgcttcagtgacttcccccttacagagcacgga
ttgattaaatgtggaatacgactgttttttgaaataaatgtggtggagaaattcaaagta
cctgtagaggttcttaccagatggatgtacactgtgaggaaagggtaccgagctgtcact
taccacaattggcggcatgggttcaacgtggggcagaccatgtttactttgctgatgaca
ggaagattaaagaagtactacacagatctcgaagcctttgccatgcttgctgctgctttc
tgccatgatattgaccacagaggcaccaataatttgtaccagatgaaatccacgtctcca
ttagcaagacttcatggttcttctattttggagaggcaccacctggagtacagtaagact
ctgttgcaggatgagagtttaaacatcttccagaacctaaataagcggcagtttgaaaca
gttattcatttgttcgaggtcgcaataatagcaactgacctggctttatatttcaagaag
aggaccatgtttcaaaaaattgttgatgcctgtgaacaaatgcaaacggaagaagaagcc
atcaaatatgtaactgttgatccaaccaagaaagagattatcatggcaatgatgatgacg
gcatgtgacttgtctgctattaccaagccctgggaggtgcaaagtcaggtagcacttatg
gttgcaaatgaattttgggaacaaggagatctggagagaacagtgttgcagcaacaaccc
attcctatgatggacagaaacaaaagagatgaattacctaaacttcaagttggatttatt
gattttgtttgtacttttgtatataaggagttctcacggtttcacaaagaaatcacacct
atgctgagtggtcttcagaataacagagtagaatggaaatcactagctgatgagtatgat
gcaaagatgaaggtcattgaagaggaggcaaaaaagcaagaaggaggagccgaaaaagct
gctgaagattcaggaggtggtgatgacaaaaagtccaaaacatgtttaatgttgtaa
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