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Homo sapiens (human): 6714
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Entry
6714 CDS
T01001
Symbol
SRC, ASV, SRC1, THC6, c-SRC, p60-Src
Name
(RefSeq) SRC proto-oncogene, non-receptor tyrosine kinase
KO
K05704
tyrosine-protein kinase Src [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04012
ErbB signaling pathway
hsa04015
Rap1 signaling pathway
hsa04062
Chemokine signaling pathway
hsa04137
Mitophagy - animal
hsa04144
Endocytosis
hsa04360
Axon guidance
hsa04370
VEGF signaling pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04625
C-type lectin receptor signaling pathway
hsa04727
GABAergic synapse
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04810
Regulation of actin cytoskeleton
hsa04912
GnRH signaling pathway
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04921
Oxytocin signaling pathway
hsa04926
Relaxin signaling pathway
hsa05100
Bacterial invasion of epithelial cells
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05135
Yersinia infection
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05219
Bladder cancer
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06162
Hepatitis B virus (HBV)
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06230
Cell cycle (cancer)
nt06263
Hepatocellular carcinoma
nt06533
Chemokine signaling
Element
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00394
HCMV gH to ITGA/B-RhoA signaling pathway
N00538
Ca2+-PYK2-RAS-ERK signaling pathway
N00540
HBV HBx to RAS-ERK signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01078
EGF-EGFR-Actin signaling pathway
N01079
Shigella IpaC to Actin signaling pathway
N01091
Escherichia EspJ to IGG-FCGR-RAC signaling pathway
N01336
CHRNA7-E2F signaling pathway
N01337
NNK/NNN to CHRNA7-E2F signaling pathway
N01351
E2-ER-RAS-ERK signaling pathway
N01352
BPA to RAS-ERK signaling pathway
N01353
E2 to RAS-ERK signaling pathway
N01358
P4-PR-PI3K signaling pathway
N01359
P4/MPA to PR-PI3K signaling pathway
N01360
P4-PR-RAS-ERK signaling pathway
N01361
P4/MPA to PR-RAS-ERK signaling pathway
N01411
Metals to NFKB signaling pathway
N01767
CXCR4-GNAI-Src signaling pathway
Disease
H00978
Thrombocytopenia (THC)
Drug target
Bosutinib (
DG00718
):
D03252
D09728
<JP/US>
Dasatinib (
DG00714
):
D03658
<JP>
D06414
<JP/US>
D12609
Ilorasertib:
D10423
Saracatinib (
DG01418
):
D09664
D09665
Tirbanibulin (
DG03082
):
D11691
<US>
D11692
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
6714 (SRC)
04015 Rap1 signaling pathway
6714 (SRC)
04370 VEGF signaling pathway
6714 (SRC)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
6714 (SRC)
04137 Mitophagy - animal
6714 (SRC)
09144 Cellular community - eukaryotes
04510 Focal adhesion
6714 (SRC)
04520 Adherens junction
6714 (SRC)
04530 Tight junction
6714 (SRC)
04540 Gap junction
6714 (SRC)
09142 Cell motility
04810 Regulation of actin cytoskeleton
6714 (SRC)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6714 (SRC)
04613 Neutrophil extracellular trap formation
6714 (SRC)
04625 C-type lectin receptor signaling pathway
6714 (SRC)
04062 Chemokine signaling pathway
6714 (SRC)
09152 Endocrine system
04912 GnRH signaling pathway
6714 (SRC)
04915 Estrogen signaling pathway
6714 (SRC)
04917 Prolactin signaling pathway
6714 (SRC)
04921 Oxytocin signaling pathway
6714 (SRC)
04926 Relaxin signaling pathway
6714 (SRC)
04919 Thyroid hormone signaling pathway
6714 (SRC)
09156 Nervous system
04727 GABAergic synapse
6714 (SRC)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
6714 (SRC)
09158 Development and regeneration
04360 Axon guidance
6714 (SRC)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
6714 (SRC)
05207 Chemical carcinogenesis - receptor activation
6714 (SRC)
05208 Chemical carcinogenesis - reactive oxygen species
6714 (SRC)
05203 Viral carcinogenesis
6714 (SRC)
09162 Cancer: specific types
05219 Bladder cancer
6714 (SRC)
09172 Infectious disease: viral
05161 Hepatitis B
6714 (SRC)
05168 Herpes simplex virus 1 infection
6714 (SRC)
05163 Human cytomegalovirus infection
6714 (SRC)
05167 Kaposi sarcoma-associated herpesvirus infection
6714 (SRC)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
6714 (SRC)
05130 Pathogenic Escherichia coli infection
6714 (SRC)
05131 Shigellosis
6714 (SRC)
05135 Yersinia infection
6714 (SRC)
05152 Tuberculosis
6714 (SRC)
05100 Bacterial invasion of epithelial cells
6714 (SRC)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
6714 (SRC)
05418 Fluid shear stress and atherosclerosis
6714 (SRC)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
6714 (SRC)
01522 Endocrine resistance
6714 (SRC)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6714 (SRC)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
6714 (SRC)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6714 (SRC)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
6714 (SRC)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
6714 (SRC)
Endocytosis
Clathrin-mediated endocytosis
Kinases
6714 (SRC)
Lipid raft mediated endocytosis
Caveolin-mediated endocytosis
6714 (SRC)
Macropinocytosis
Kinases
6714 (SRC)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_9
SH3_2
SH2_1
SH3_10
ABC1
Haspin_kinase
SH3_3
Motif
Other DBs
NCBI-GeneID:
6714
NCBI-ProteinID:
NP_005408
OMIM:
190090
HGNC:
11283
Ensembl:
ENSG00000197122
UniProt:
P12931
Structure
PDB
LinkDB
All DBs
Position
20:37344699..37406050
Genome browser
AA seq
536 aa
AA seq
DB search
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
NT seq
1611 nt
NT seq
+upstream
nt +downstream
nt
atgggtagcaacaagagcaagcccaaggatgccagccagcggcgccgcagcctggagccc
gccgagaacgtgcacggcgctggcgggggcgctttccccgcctcgcagacccccagcaag
ccagcctcggccgacggccaccgcggccccagcgcggccttcgcccccgcggccgccgag
cccaagctgttcggaggcttcaactcctcggacaccgtcacctccccgcagagggcgggc
ccgctggccggtggagtgaccacctttgtggccctctatgactatgagtctaggacggag
acagacctgtccttcaagaaaggcgagcggctccagattgtcaacaacacagagggagac
tggtggctggcccactcgctcagcacaggacagacaggctacatccccagcaactacgtg
gcgccctccgactccatccaggctgaggagtggtattttggcaagatcaccagacgggag
tcagagcggttactgctcaatgcagagaacccgagagggaccttcctcgtgcgagaaagt
gagaccacgaaaggtgcctactgcctctcagtgtctgacttcgacaacgccaagggcctc
aacgtgaagcactacaagatccgcaagctggacagcggcggcttctacatcacctcccgc
acccagttcaacagcctgcagcagctggtggcctactactccaaacacgccgatggcctg
tgccaccgcctcaccaccgtgtgccccacgtccaagccgcagactcagggcctggccaag
gatgcctgggagatccctcgggagtcgctgcggctggaggtcaagctgggccagggctgc
tttggcgaggtgtggatggggacctggaacggtaccaccagggtggccatcaaaaccctg
aagcctggcacgatgtctccagaggccttcctgcaggaggcccaggtcatgaagaagctg
aggcatgagaagctggtgcagttgtatgctgtggtttcagaggagcccatttacatcgtc
acggagtacatgagcaaggggagtttgctggactttctcaagggggagacaggcaagtac
ctgcggctgcctcagctggtggacatggctgctcagatcgcctcaggcatggcgtacgtg
gagcggatgaactacgtccaccgggaccttcgtgcagccaacatcctggtgggagagaac
ctggtgtgcaaagtggcggactttgggctggctcggctcattgaagacaatgagtacacg
gcgcggcaaggtgccaaattccccatcaagtggacggctccagaagctgccctctatggc
cgcttcaccatcaagtcggacgtgtggtccttcgggatcctgctgactgagctcaccaca
aagggacgggtgccctaccctgggatggtgaaccgcgaggtgctggaccaggtggagcgg
ggctaccggatgccctgcccgccggagtgtcccgagtccctgcacgacctcatgtgccag
tgctggcggaaggagcctgaggagcggcccaccttcgagtacctgcaggccttcctggag
gactacttcacgtccaccgagccccagtaccagcccggggagaacctctag
DBGET
integrated database retrieval system