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Homo sapiens (human): 7298
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Entry
7298 CDS
T01001
Symbol
TYMS, DKCD, HST422, TMS, TS
Name
(RefSeq) thymidylate synthetase
KO
K00560
thymidylate synthase [EC:
2.1.1.45
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00240
Pyrimidine metabolism
hsa00670
One carbon pool by folate
hsa01100
Metabolic pathways
hsa01232
Nucleotide metabolism
hsa01523
Antifolate resistance
Module
hsa_M00938
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Disease
H00507
Dyskeratosis congenita
Drug target
Arfolitixorin (
DG03254
):
D11447
D12528
Capecitabine:
D01223
<JP/US>
Carmofur:
D01784
Doxifluridine:
D01309
<JP>
Floxuridine:
D04197
<US>
Fluorouracil (
DG00687
):
D00584
<JP/US>
D07974
Fosifloxuridine nafalbenamide:
D12388
Metesind glucuronate:
D04964
Pemetrexed (
DG00682
):
D03828
<US>
D06503
<JP/US>
D07472
<US>
D10596
<JP/US>
D11352
<US>
Plevitrexed:
D10803
Raltitrexed:
D01064
Tegafur:
D01244
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
7298 (TYMS)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
7298 (TYMS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
7298 (TYMS)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
7298 (TYMS)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Thymidylat_synt
Motif
Other DBs
NCBI-GeneID:
7298
NCBI-ProteinID:
NP_001062
OMIM:
188350
HGNC:
12441
Ensembl:
ENSG00000176890
UniProt:
P04818
Q53Y97
Structure
PDB
LinkDB
All DBs
Position
18:657653..673578
Genome browser
AA seq
313 aa
AA seq
DB search
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
NT seq
942 nt
NT seq
+upstream
nt +downstream
nt
atgcctgtggccggctcggagctgccgcgccggcccttgccccccgccgcacaggagcgg
gacgccgagccgcgtccgccgcacggggagctgcagtacctggggcagatccaacacatc
ctccgctgcggcgtcaggaaggacgaccgcacgggcaccggcaccctgtcggtattcggc
atgcaggcgcgctacagcctgagagatgaattccctctgctgacaaccaaacgtgtgttc
tggaagggtgttttggaggagttgctgtggtttatcaagggatccacaaatgctaaagag
ctgtcttccaagggagtgaaaatctgggatgccaatggatcccgagactttttggacagc
ctgggattctccaccagagaagaaggggacttgggcccagtttatggcttccagtggagg
cattttggggcagaatacagagatatggaatcagattattcaggacagggagttgaccaa
ctgcaaagagtgattgacaccatcaaaaccaaccctgacgacagaagaatcatcatgtgc
gcttggaatccaagagatcttcctctgatggcgctgcctccatgccatgccctctgccag
ttctatgtggtgaacagtgagctgtcctgccagctgtaccagagatcgggagacatgggc
ctcggtgtgcctttcaacatcgccagctacgccctgctcacgtacatgattgcgcacatc
acgggcctgaagccaggtgactttatacacactttgggagatgcacatatttacctgaat
cacatcgagccactgaaaattcagcttcagcgagaacccagacctttcccaaagctcagg
attcttcgaaaagttgagaaaattgatgacttcaaagctgaagactttcagattgaaggg
tacaatccgcatccaactattaaaatggaaatggctgtttag
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