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Homo sapiens (human): 8622
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Entry
8622 CDS
T01001
Symbol
PDE8B, ADSD, PPNAD3
Name
(RefSeq) phosphodiesterase 8B
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04927
Cortisol synthesis and secretion
hsa04934
Cushing syndrome
hsa05032
Morphine addiction
Network
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00323
Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Disease
H00260
Pigmented micronodular adrenocortical disease
H01431
Cushing syndrome
H01570
Autosomal dominant striatal degeneration
Drug target
Aminophylline (
DG01062
):
D00227
D05429
<JP>
D11630
<US>
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
<JP>
D07546
Choline theophyllinate:
D02017
Diprophylline:
D00691
<JP>
Enprofylline:
D04006
Flavoxate (
DG00477
):
D00718
<JP/US>
D07961
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
<JP>
D07425
D07439
Prinoxodan:
D05612
Proxyphylline:
D01771
<JP>
Theophylline (
DG01061
):
D00371
<JP/US>
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Trapidil:
D01220
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
8622 (PDE8B)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
8622 (PDE8B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
8622 (PDE8B)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
8622 (PDE8B)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
8622 (PDE8B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDE8
PAS_9
PAS
PAS_3
PAS_4
PAS_8
DUF4194
DHH
Motif
Other DBs
NCBI-GeneID:
8622
NCBI-ProteinID:
NP_003710
OMIM:
603390
HGNC:
8794
Ensembl:
ENSG00000113231
UniProt:
O95263
B3KN77
LinkDB
All DBs
Position
5:77086715..77428256
Genome browser
AA seq
885 aa
AA seq
DB search
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
NT seq
2658 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgcccccagcatccatgtctcgcagagcggcgtgatctactgccgggactcg
gacgagtccagctcgccccgccagaccaccagcgtgtcgcagggcccggcggcacccctg
cccggcctcttcgtccagaccgacgccgccgacgccatccccccgagccgcgcgtcggga
ccccccagcgtagcccgcgtccgcagggcccgcaccgagctgggcagcggtagcagcgcg
ggttccgcagcccccgccgcgaccaccagcaggggccggaggcgccactgctgcagcagc
gccgaggccgagactcagacctgctacaccagcgtgaagcaggtgtcttctgcggaggtg
cgcatcgggcccatgagactgacgcaggaccctattcaggttttgctgatctttgcaaag
gaagatagtcagagcgatggcttctggtgggcctgcgacagagctggttatagatgcaat
attgctcggactccagagtcagcccttgaatgctttcttgataagcatcatgaaattatt
gtaattgatcatagacaaactcagaacttcgatgcagaagcagtgtgcaggtcgatccgg
gccacaaatccctccgagcacacggtgatcctcgcagtggtttcgcgagtatcggatgac
catgaagaggcgtcagtccttcctcttctccacgcaggcttcaacaggagatttatggag
aatagcagcataattgcttgctataatgaactgattcaaatagaacatggggaagttcgc
tcccagttcaaattacgggcctgtaattcagtgtttacagcattagatcactgtcatgaa
gccatagaaataacaagcgatgaccacgtgattcagtatgtcaacccagccttcgaaagg
atgatgggctaccacaaaggtgagctcctgggaaaagaactcgctgatctgcccaaaagc
gataagaaccgggcagaccttctcgacaccatcaatacatgcatcaagaagggaaaggag
tggcagggggtttactatgccagacggaaatccggggacagcatccaacagcacgtgaag
atcaccccagtgattggccaaggagggaaaattaggcattttgtctcgctcaagaaactg
tgttgtaccactgacaataataagcagattcacaagattcatcgtgattcaggagacaat
tctcagacagagcctcattcattcagatataagaacaggaggaaagagtccattgacgtg
aaatcgatatcatctcgaggcagtgatgcaccaagcctgcagaatcgtcgctatccgtcc
atggcgaggatccactccatgaccatcgaggctcccatcacaaaggttataaatataatc
aatgcagcccaagaaaacagcccagtcacagtagcggaagccttggacagagttctagag
attttacggaccacagaactgtactcccctcagctgggtaccaaagatgaagatccccac
accagtgatcttgttggaggcctgatgactgacggcttgagaagactgtcaggaaacgag
tatgtgtttactaagaatgtgcaccagagtcacagtcaccttgcaatgccaataaccatc
aatgatgttcccccttgtatctctcaattacttgataatgaggagagttgggacttcaac
atctttgaattggaagccattacgcataaaaggccattggtttatctgggcttaaaggtc
ttctctcggtttggagtatgtgaatttttaaactgttctgaaaccactcttcgggcctgg
ttccaagtgatcgaagccaactaccactcttccaatgcctaccacaactccacccatgct
gccgacgtcctgcacgccaccgctttctttcttggaaaggaaagagtaaagggaagcctc
gatcagttggatgaggtggcagccctcattgctgccacagtccatgacgtggatcacccg
ggaaggaccaactctttcctctgcaatgcaggcagtgagcttgctgtgctctacaatgac
actgctgttctggagagtcaccacaccgccctggccttccagctcacggtcaaggacacc
aaatgcaacattttcaagaatattgacaggaaccattatcgaacgctgcgccaggctatt
attgacatggttttggcaacagagatgacaaaacactttgaacatgtgaataagtttgtg
aacagcatcaacaagccaatggcagctgagattgaaggcagcgactgtgaatgcaaccct
gctgggaagaacttccctgaaaaccaaatcctgatcaaacgcatgatgattaagtgtgct
gacgtggccaacccatgccgccccttggacctgtgcattgaatgggctgggaggatctct
gaggagtattttgcacagactgatgaagagaagagacagggactacctgtggtgatgcca
gtgtttgaccggaatacctgtagcatccccaagtctcagatctctttcattgactacttc
ataacagacatgtttgatgcttgggatgcctttgcacatctgccagccctgatgcaacat
ttggctgacaactacaaacactggaagacactagatgacctaaagtgcaaaagtttgagg
cttccatctgacagctaa
DBGET
integrated database retrieval system