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Homo sapiens (human): 6098
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Entry
6098 CDS
T01001
Symbol
ROS1, MCF3, ROS, c-ros-1
Name
(RefSeq) ROS proto-oncogene 1, receptor tyrosine kinase
KO
K05088
proto-oncogene tyrosine-protein kinase ROS [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Disease
H00014
Non-small cell lung cancer
Drug target
Crizotinib:
D09731
<JP/US>
Entrectinib:
D10926
<JP/US>
Lorlatinib:
D11012
<JP/US>
Repotrectinib:
D11454
<US>
Taletrectinib (
DG03226
):
D12363
D12364
Zidesamtinib:
D12899
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6098 (ROS1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
6098 (ROS1)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
ROS family
6098 (ROS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
fn3
Pkinase
Pur_ac_phosph_N
Motif
Other DBs
NCBI-GeneID:
6098
NCBI-ProteinID:
NP_002935
OMIM:
165020
HGNC:
10261
Ensembl:
ENSG00000047936
UniProt:
P08922
Structure
PDB
LinkDB
All DBs
Position
6:complement(117287353..117425942)
Genome browser
AA seq
2347 aa
AA seq
DB search
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQG
CHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWK
SANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS
PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLD
AGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTS
LRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR
IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYN
GYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMST
FLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF
GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFEL
GPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPW
SEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS
DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTD
IVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDL
SDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWING
FRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEG
NASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTP
YTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLT
KFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYA
DVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAE
GDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKV
KYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQ
QNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAML
AGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFP
DKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNS
SDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEA
VQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTL
LVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPL
NVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENST
SLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQN
LRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPET
SFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLAN
ACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVK
TLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI
GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATE
CGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHS
GYGDGSD
NT seq
7044 nt
NT seq
+upstream
nt +downstream
nt
atgaagaacatttactgtcttattccgaagcttgtcaattttgcaactcttggctgccta
tggatttctgtggtgcagtgtacagttttaaatagctgcctaaagtcgtgtgtaactaat
ctgggccagcagcttgaccttggcacaccacataatctgagtgaaccgtgtatccaagga
tgtcacttttggaactctgtagatcagaaaaactgtgctttaaagtgtcgggagtcgtgt
gaggttggctgtagcagcgcggaaggtgcatatgaagaggaagtactggaaaatgcagac
ctaccaactgctccctttgcttcttccattggaagccacaatatgacattacgatggaaa
tctgcaaacttctctggagtaaaatacatcattcagtggaaatatgcacaacttctggga
agctggacttatactaagactgtgtccagaccgtcctatgtggtcaagcccctgcacccc
ttcactgagtacattttccgagtggtttggatcttcacagcgcagctgcagctctactcc
cctccaagtcccagttacaggactcatcctcatggagttcctgaaactgcacctttgatt
aggaatattgagagctcaagtcccgacactgtggaagtcagctgggatccacctcaattc
ccaggtggacctattttgggttataacttaaggctgatcagcaaaaatcaaaaattagat
gcagggacacagagaaccagtttccagttttactccactttaccaaatactatctacagg
ttttctattgcagcagtaaatgaagttggtgagggtccagaagcagaatctagtattacc
acttcatcttcagcagttcaacaagaggaacagtggctctttttatccagaaaaacttct
ctaagaaagagatctttaaaacatttagtagatgaagcacattgccttcggttggatgct
atataccataatattacaggaatatctgttgatgtccaccagcaaattgtttatttctct
gaaggaactctcatatgggcgaagaaggctgccaacatgtctgatgtatctgacctgaga
attttttacagaggttcaggattaatttcttctatctccatagattggctttatcaaaga
atgtatttcatcatggatgaactggtatgtgtctgtgatttagagaactgctcaaacatc
gaggaaattactccaccctctattagtgcacctcaaaaaattgtggctgattcatacaat
gggtatgtcttttacctcctgagagatggcatttatagagcagaccttcctgtaccatct
ggccggtgtgcagaagctgtgcgtattgtggagagttgcacgttaaaggactttgcaatc
aagccacaagccaagcgaatcatttacttcaatgacactgcccaagtcttcatgtcaaca
tttctggatggctctgcttcccatctcatcctacctcgcatcccctttgctgatgtgaaa
agttttgcttgtgaaaacaatgactttcttgtcacagatggcaaggtcattttccaacag
gatgctttgtcttttaatgaattcatcgtgggatgtgacctgagtcacatagaagaattt
gggtttggtaacttggtcatctttggctcatcctcccagctgcaccctctgccaggccgc
ccgcaggagctttcggtgctgtttggctctcaccaggctcttgttcaatggaagcctcct
gcccttgccataggagccaatgtcatcctgatcagtgatattattgaactctttgaatta
ggcccttctgcctggcagaactggacctatgaggtgaaagtatccacccaagaccctcct
gaagtcactcatattttcttgaacataagtggaaccatgctgaatgtacctgagctgcag
agtgctatgaaatacaaggtttctgtgagagcaagttctccaaagaggccaggcccctgg
tcagagccctcagtgggtactaccctggtgccagctagtgaaccaccatttatcatggct
gtgaaagaagatgggctttggagtaaaccattaaatagctttggcccaggagagttctta
tcctctgatataggaaatgtgtcagacatggattggtataacaacagcctctactacagt
gacacgaaaggcgacgtttttgtgtggctgctgaatgggacggatatctcagagaattat
cacctacccagcattgcaggagcaggggctttagcttttgagtggctgggtcactttctc
tactgggctggaaagacatatgtgatacaaaggcagtctgtgttgacgggacacacagac
attgttacccacgtgaagctattggtgaatgacatggtggtggattcagttggtggatat
ctctactggaccacactctattcagtggaaagcaccagactaaatggggaaagttccctt
gtactacagacacagccttggttttctgggaaaaaggtaattgctctaactttagacctc
agtgatgggctcctgtattggttggttcaagacagtcaatgtattcacctgtacacagct
gttcttcggggacagagcactggggataccaccatcacagaatttgcagcctggagtact
tctgaaatttcccagaatgcactgatgtactatagtggtcggctgttctggatcaatggc
tttaggattatcacaactcaagaaataggtcagaaaaccagtgtctctgttttggaacca
gccagatttaatcagttcacaattattcagacatcccttaagcccctgccagggaacttt
tcctttacccctaaggttattccagattctgttcaagagtcttcatttaggattgaagga
aatgcttcaagttttcaaatcctgtggaatggtccccctgcggtagactggggtgtagtt
ttctacagtgtagaatttagtgctcattctaagttcttggctagtgaacaacactcttta
cctgtatttactgtggaaggactggaaccttatgccttatttaatctttctgtcactcct
tatacctactggggaaagggccccaaaacatctctgtcacttcgagcacctgaaacagtt
ccatcagcaccagagaaccccagaatatttatattaccaagtggaaaatgctgcaacaag
aatgaagttgtggtggaatttaggtggaacaaacctaagcatgaaaatggggtgttaaca
aaatttgaaattttctacaatatatccaatcaaagtattacaaacaaaacatgtgaagac
tggattgctgtcaatgtcactccctcagtgatgtcttttcaacttgaaggcatgagtccc
agatgctttattgccttccaggttagggcctttacatctaaggggccaggaccatatgct
gacgttgtaaagtctacaacatcagaaatcaacccatttcctcacctcataactcttctt
ggtaacaagatagtttttttagatatggatcaaaatcaagttgtgtggacgttttcagca
gaaagagttatcagtgccgtttgctacacagctgataatgagatgggatattatgctgaa
ggggactcactctttcttctgcacttgcacaatcgctctagctctgagcttttccaagat
tcactggtttttgatatcacagttattacaattgactggatttcaaggcacctctacttt
gcactgaaagaatcacaaaatggaatgcaagtatttgatgttgatcttgaacacaaggtg
aaatatcccagagaggtgaagattcacaataggaattcaacaataatttctttttctgta
tatcctcttttaagtcgcttgtattggacagaagtttccaattttggctaccagatgttc
tactacagtattatcagtcacaccttgcaccgaattctgcaacccacagctacaaaccaa
caaaacaaaaggaatcaatgttcttgtaatgtgactgaatttgagttaagtggagcaatg
gctattgatacctctaacctagagaaaccattgatatactttgccaaagcacaagagatc
tgggcaatggatctggaaggctgtcagtgttggagagttatcacagtacctgctatgctc
gcaggaaaaacccttgttagcttaactgtggatggagatcttatatactggatcatcaca
gcaaaggacagcacacagatttatcaggcaaagaaaggaaatggggccatcgtttcccag
gtgaaggccctaaggagtaggcatatcttggcttacagttcagttatgcagccttttcca
gataaagcgtttctgtctctagcttcagacactgtggaaccaactatacttaatgccact
aacactagcctcacaatcagattacctctggccaagacaaacctcacatggtatggcatc
accagccctactccaacatacctggtttattatgcagaagttaatgacaggaaaaacagc
tctgacttgaaatatagaattctggaatttcaggacagtatagctcttattgaagattta
caaccattttcaacatacatgatacagatagctgtaaaaaattattattcagatcctttg
gaacatttaccaccaggaaaagagatttggggaaaaactaaaaatggagtaccagaggca
gtgcagctcattaatacaactgtgcggtcagacaccagcctcattatatcttggagagaa
tctcacaagccaaatggacctaaagaatcagtccgttatcagttggcaatctcacacctg
gccctaattcctgaaactcctctaagacaaagtgaatttccaaatggaaggctcactctc
cttgttactagactgtctggtggaaatatttatgtgttaaaggttcttgcctgccactct
gaggaaatgtggtgtacagagagtcatcctgtcactgtggaaatgtttaacacaccagag
aaaccttattccttggttccagagaacactagtttgcaatttaattggaaggctccattg
aatgttaacctcatcagattttgggttgagctacagaagtggaaatacaatgagttttac
catgttaaaacttcatgcagccaaggtcctgcttatgtctgtaatatcacaaatctacaa
ccttatacttcatataatgtcagagtagtggtggtttataagacgggagaaaatagcacc
tcacttccagaaagctttaagacaaaagctggagtcccaaataaaccaggcattcccaaa
ttactagaagggagtaaaaattcaatacagtgggagaaagctgaagataatggatgtaga
attacatactatatccttgagataagaaagagcacttcaaataatttacagaaccagaat
ttaaggtggaagatgacatttaatggatcctgcagtagtgtttgcacatggaagtccaaa
aacctgaaaggaatatttcagttcagagtagtagctgcaaataatctagggtttggtgaa
tatagtggaatcagtgagaatattatattagttggagatgatttttggataccagaaaca
agtttcatacttactattatagttggaatatttctggttgttacaatcccactgaccttt
gtctggcatagaagattaaagaatcaaaaaagtgccaaggaaggggtgacagtgcttata
aacgaagacaaagagttggctgagctgcgaggtctggcagccggagtaggcctggctaat
gcctgctatgcaatacatactcttccaacccaagaggagattgaaaatcttcctgccttc
cctcgggaaaaactgactctgcgtctcttgctgggaagtggagcctttggagaagtgtat
gaaggaacagcagtggacatcttaggagttggaagtggagaaatcaaagtagcagtgaag
actttgaagaagggttccacagaccaggagaagattgaattcctgaaggaggcacatctg
atgagcaaatttaatcatcccaacattctgaagcagcttggagtttgtctgctgaatgaa
ccccaatacattatcctggaactgatggagggaggagaccttcttacttatttgcgtaaa
gcccggatggcaacgttttatggtcctttactcaccttggttgaccttgtagacctgtgt
gtagatatttcaaaaggctgtgtctacttggaacggatgcatttcattcacagggatctg
gcagctagaaattgccttgtttccgtgaaagactataccagtccacggatagtgaagatt
ggagactttggactcgccagagacatctataaaaatgattactatagaaagagaggggaa
ggcctgctcccagttcggtggatggctccagaaagtttgatggatggaatcttcactact
caatctgatgtatggtcttttggaattctgatttgggagattttaactcttggtcatcag
ccttatccagctcattccaaccttgatgtgttaaactatgtgcaaacaggagggagactg
gagccaccaagaaattgtcctgatgatctgtggaatttaatgacccagtgctgggctcaa
gaacccgaccaaagacctacttttcatagaattcaggaccaacttcagttattcagaaat
tttttcttaaatagcatttataagtccagagatgaagcaaacaacagtggagtcataaat
gaaagctttgaaggtgaagatggcgatgtgatttgtttgaattcagatgacattatgcca
gttgctttaatggaaacgaagaaccgagaagggttaaactatatggtacttgctacagaa
tgtggccaaggtgaagaaaagtctgagggtcctctaggctcccaggaatctgaatcttgt
ggtctgaggaaagaagagaaggaaccacatgcagacaaagatttctgccaagaaaaacaa
gtggcttactgcccttctggcaagcctgaaggcctgaactatgcctgtctcactcacagt
ggatatggagatgggtctgattaa
DBGET
integrated database retrieval system