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Mirounga leonina (Southern elephant seal): 118026348
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Entry
118026348 CDS
T07472
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx01521
EGFR tyrosine kinase inhibitor resistance
mlx04062
Chemokine signaling pathway
mlx04148
Efferocytosis
mlx04151
PI3K-Akt signaling pathway
mlx04217
Necroptosis
mlx04550
Signaling pathways regulating pluripotency of stem cells
mlx04630
JAK-STAT signaling pathway
mlx04658
Th1 and Th2 cell differentiation
mlx04659
Th17 cell differentiation
mlx04725
Cholinergic synapse
mlx04917
Prolactin signaling pathway
mlx04920
Adipocytokine signaling pathway
mlx04933
AGE-RAGE signaling pathway in diabetic complications
mlx04935
Growth hormone synthesis, secretion and action
mlx05140
Leishmaniasis
mlx05145
Toxoplasmosis
mlx05152
Tuberculosis
mlx05161
Hepatitis B
mlx05164
Influenza A
mlx05167
Kaposi sarcoma-associated herpesvirus infection
mlx05168
Herpes simplex virus 1 infection
mlx05200
Pathways in cancer
mlx05207
Chemical carcinogenesis - receptor activation
mlx05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mlx05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
118026348 (JAK2)
04151 PI3K-Akt signaling pathway
118026348 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
118026348 (JAK2)
09143 Cell growth and death
04217 Necroptosis
118026348 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
118026348 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
118026348 (JAK2)
04659 Th17 cell differentiation
118026348 (JAK2)
04062 Chemokine signaling pathway
118026348 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
118026348 (JAK2)
04917 Prolactin signaling pathway
118026348 (JAK2)
04935 Growth hormone synthesis, secretion and action
118026348 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
118026348 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
118026348 (JAK2)
05207 Chemical carcinogenesis - receptor activation
118026348 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
118026348 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
118026348 (JAK2)
05164 Influenza A
118026348 (JAK2)
05168 Herpes simplex virus 1 infection
118026348 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
118026348 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
118026348 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
118026348 (JAK2)
05140 Leishmaniasis
118026348 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
118026348 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
118026348 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
118026348 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mlx01001
]
118026348 (JAK2)
Enzymes [BR:
mlx01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
118026348 (JAK2)
Protein kinases [BR:
mlx01001
]
Non-receptor tyrosine kinases
JAK family [OT]
118026348 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
SH2
ABC1
FERM_C_FAK1
RIO1
Kinase-like
FERM_M
Motif
Other DBs
NCBI-GeneID:
118026348
NCBI-ProteinID:
XP_034885038
LinkDB
All DBs
Position
Unknown
AA seq
1130 aa
AA seq
DB search
MACLTMTEMEGTSVSPVQQNGDIPGNANPMKQIDPLLQVYLYHSLEKAEGEYLKFPTGEY
VAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPY
WYCNGSNRTYRHGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLGMA
VLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSH
CKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK
HKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLREA
LSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQTGL
YVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNCYQ
METVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKIRN
EDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS
QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMH
FLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPE
CIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELAN
LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPT
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL
KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICK
GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA
PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL
KNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq
3393 nt
NT seq
+upstream
nt +downstream
nt
atggcttgccttacaatgacagaaatggaaggaacatccgtatctcctgtacaacagaat
ggtgatattcctggaaatgcgaatcccatgaagcaaatagatccactcctacaggtgtat
ctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggggagtat
gttgcagaagaaatttgtgttgctgcttctaaagcttgtggaatcacacctgtgtatcat
agtatgtttgctttaatgagtgaaacagaaaggatttggtatccgcccaaccatgtcttc
catatagatgaatcaaccaggcacaatgtactctacagaataagattttactttccttac
tggtattgtaacggcagcaacagaacctatcggcatgggatatctcgaggtgccgaagct
cctcttcttgacgactttgtcatggcctacctttttgctcagtggcggcatgatttttta
catggatggataaaaatacccgtgacccatgaaacacaggaagaatgtcttggaatggct
gtgttagatatgatgagactagccaaagagaaggatcagaccccactggacatctatagc
tctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagactatcat
attttgacaaggaaacgaataaggtacagatttcgcagatttattgagcaattcagccat
tgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag
tctgccttctacacagagcagtttgaagtaaaagaacctggaagaggtccttcaggtgag
gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa
cataaagaaagtgagacactgacagaacaggatttacagttatattgtgactttcctgat
attattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtagaattgta
actatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagagaagct
ttgtcctttgtgtcattaattgatggctattatagattaactgcagatgcacatcattac
ctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgtcatggc
ccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagactggactc
tatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgctgtagag
cgagaaaatgtcatcgaatataagcactgtttgattacaaaaaatgagaatggagaatac
aacctcagtgggaccaagaagaacttcagtaatcttaaagatcttttgaattgctatcaa
atggaaactgttcgctcagacagtataattttccagtttactaaatgctgtcccccaaag
ttgaaagataaatcaaaccttctagtcttcagaaccaatggcgtttctgatgttccaaca
tcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatcagaaat
gaagatttgatgtttaatgaaagccttggtcaaggcacttttacaaaaatttttaaaggt
ataagaagagaagtaggagactatggtcaactacatgaaacagaagttctgttaaaagtt
ctggataaagcgcacagaaactattcagagtctttctttgaagcagccagcatgatgagc
cagctttctcacaagcatctggttttaaattacggagtatgtgtctgtggggaagagaat
attctggttcaagagtttgtaaaatttggatcactagatacatatctgaaaaagaataaa
aattctataaatatattatggaaacttgaagtggctaaacaattggcatgggccatgcat
tttctagaagaaaaagcacttattcatgggaatgtgtgtgccaaaaatattctgcttatc
agagaagaagacaggaaaacaggaaatcctcctttcatcaaacttagtgatcctggcatt
agtattacagttttgccaaaggacattcttcaggagagaataccatgggtaccacctgaa
tgcatcgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggtaccact
ttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaaagaaag
ctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaattagcaaat
cttattaataattgtatggattatgaaccagattttagaccttctttcagagccatcata
cgagatcttaatagtttgtttactccagattatgaactattaacagagaatgacatgtta
ccaaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagaccctacg
cagtttgaagagagacacttgaaatttctacagcaacttggtaagggtaattttggcagt
gtggagatgtgccggtatgaccctctacaagacaacactggggaggtggtggctgtgaag
aagctccagcacagcactgaggagcacctgagagactttgagagggaaatcgaaatcctt
aaatccctgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgctggtcgg
cgtaatctaagattaattatggaatatttaccatatggaagtttacgagactatctccaa
aaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgcaag
ggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaggaatata
ttggtggaaaacgaaaacagggttaaaattggagattttgggttaaccaaagtcttgcca
caagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtatgct
ccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttggagtg
gttctgtatgaacttttcacatatattgagaagagtaaaagtcccccagcggaatttatg
cgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactccta
aagaataatggaagattaccaagaccagatggatgtccagatgagatttatttgatcatg
acagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagctcttcga
gttgatcaaataagggacaacatggctggatga
DBGET
integrated database retrieval system