Mustela putorius furo (domestic ferret): 101671881 Help Entry 101671881         CDS       T07239                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism mpuf  Mustela putorius furo (domestic ferret) Pathway mpuf01521   EGFR tyrosine kinase inhibitor resistance mpuf04062   Chemokine signaling pathway mpuf04148   Efferocytosis mpuf04151   PI3K-Akt signaling pathway mpuf04217   Necroptosis mpuf04550   Signaling pathways regulating pluripotency of stem cells mpuf04630   JAK-STAT signaling pathway mpuf04658   Th1 and Th2 cell differentiation mpuf04659   Th17 cell differentiation mpuf04725   Cholinergic synapse mpuf04917   Prolactin signaling pathway mpuf04920   Adipocytokine signaling pathway mpuf04933   AGE-RAGE signaling pathway in diabetic complications mpuf04935   Growth hormone synthesis, secretion and action mpuf05140   Leishmaniasis mpuf05145   Toxoplasmosis mpuf05152   Tuberculosis mpuf05161   Hepatitis B mpuf05164   Influenza A mpuf05167   Kaposi sarcoma-associated herpesvirus infection mpuf05168   Herpes simplex virus 1 infection mpuf05200   Pathways in cancer mpuf05207   Chemical carcinogenesis - receptor activation mpuf05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mpuf05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mpuf00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101671881 (JAK2)    04151 PI3K-Akt signaling pathway     101671881 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     101671881 (JAK2)   09143 Cell growth and death    04217 Necroptosis     101671881 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101671881 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101671881 (JAK2)    04659 Th17 cell differentiation     101671881 (JAK2)    04062 Chemokine signaling pathway     101671881 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     101671881 (JAK2)    04917 Prolactin signaling pathway     101671881 (JAK2)    04935 Growth hormone synthesis, secretion and action     101671881 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     101671881 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101671881 (JAK2)    05207 Chemical carcinogenesis - receptor activation     101671881 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101671881 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     101671881 (JAK2)    05164 Influenza A     101671881 (JAK2)    05168 Herpes simplex virus 1 infection     101671881 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     101671881 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     101671881 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101671881 (JAK2)    05140 Leishmaniasis     101671881 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101671881 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101671881 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101671881 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mpuf01001]     101671881 (JAK2) Enzymes [BR:mpuf01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101671881 (JAK2) Protein kinases [BR:mpuf01001]  Non-receptor tyrosine kinases   JAK family [OT]    101671881 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  101671881 NCBI-ProteinID:  XP_004766235 Ensembl:  ENSMPUG00000004974 UniProt:  M3Y0T4 LinkDB All DBs Position Unknown AA seq 1130 aa AA seqDB search MACLTMTEMEGTSVSPVHQNGDVPGNANPVKQIDPLLQVYLYHSLEKAEGEYLKFPTGEY AAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPY WYCNGSNRTYRYGISRGAETPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLGMA VLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSH CKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK HKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLKEA LSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQTGL YVLRCSPKDFNKYFLTFAVERENAIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNCYQ METVRSDSIIFQFTKCCPPKLKDKSNLLVFRTSGISDVPTSPTLQRHNNVNQMVFHKIRN EDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMH FLEEKALVHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPE CTENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELAN LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPT QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICK GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL KNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG NT seq 3393 nt NT seq  +upstreamnt  +downstreamnt atggcttgccttacaatgacagaaatggaaggaacgtccgtatcccctgtacatcagaac ggtgatgttcctggaaatgctaatccggtgaagcaaatagatccactcctacaggtgtat ctttaccattctcttgagaaagctgaaggagagtatctgaagtttccaactggggagtat gctgcagaagaaatctgtgttgctgcttctaaagcttgtggaatcacacctgtgtatcat agtatgtttgctttaatgagtgaaacagaaaggatttggtatccgcccaaccatgtcttc catatagatgaatcaaccaggcacaatgtactctacagaataagattttactttccttac tggtattgtaacggcagcaacagaacctatcggtatgggatatctcgaggtgctgaaact cctcttcttgacgactttgtcatggcctacctttttgctcagtggcggcatgatttttta catggatggataaaaatacctgtgactcatgaaacacaagaagaatgtcttggaatggct gtgttagatatgatgagactagccaaagagaaagatcagaccccattggacatctatagc tctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagactatcat attttgacaaggaaacgaataaggtacagatttcgcagatttattgagcagttcagccat tgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag tcagccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttcaggtgag gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa cataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttccctgat attattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtagaattgta actatacataagcaagatggtaaaaatctggaaattgaacttagctcattaaaagaagct ttgtcctttgtgtcattaattgatggctattatagattaactgcagatgcacatcattac ctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgtcatggc ccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagactggactc tacgtacttcgatgcagtcctaaggattttaataagtattttctgacttttgctgttgag cgagaaaatgccattgaatataagcactgtttgattacaaagaatgaaaatggagaatac aacctcagtgggaccaagaagaacttcagtaaccttaaagatcttttgaattgctaccag atggaaactgttcgctcagacagtataattttccagtttactaaatgttgtcccccaaag ttgaaagataaatcaaaccttctagtcttcagaaccagtggcatttctgatgttcccaca tcaccaacattacagaggcacaataatgtgaaccaaatggtgtttcacaaaatcagaaat gaagatttgatgtttaatgaaagccttggccaaggcacttttacaaaaatttttaaaggt ataaggagagaagtaggagattatggtcaactacatgaaacagaagttcttttaaaagtt ctggataaagctcacagaaactattccgagtctttctttgaagcagcaagcatgatgagc cagctttctcacaagcatctagttttaaattatggagtgtgtgtctgtggggaggagaat attctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaagaataaa aattctataaatatattatggaaacttgaagtggctaaacagttggcatgggccatgcat tttctagaagaaaaagcacttgttcatgggaatgtgtgtgccaaaaacattctgcttatc agagaagaagacaggaagacaggaaaccctcctttcatcaaactcagtgaccctggcatt agcattacagttttgccaaaggacattcttcaggagagaataccatgggtaccacctgaa tgcactgaaaatcctaaaaatctaaatttggcgacagacaaatggagttttggtaccact ttgtgggaaatctgcagtggaggagataaacctctgagtgctttggattctcaaagaaag ctacagttttacgaagataggcaccagcttcctgcaccaaagtggacagaattagcaaat cttattaataattgtatggattatgaaccagatttcagaccttctttcagagccatcata cgagatcttaatagtttgtttactccagattatgaactactaacagaaaatgacatgtta ccaaatatgagaataggtgccctggggttttctggtgcttttgaagaccgagaccctaca caatttgaagagagacacttgaaatttctacagcaacttggcaagggtaattttggcagc gtggagatgtgccggtatgaccccctgcaggacaacactggggaggtggtggctgtgaag aagctccagcacagtactgaggagcacctgagagactttgagagggagattgaaatcctg aaatccctgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgctggtcgg cgtaatctaagattaattatggaatatttaccatatggaagtttacgagactatctccaa aaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgcaag ggcatggagtatcttggtacaaaaagatatatccacagggatctggcaacaaggaatata ttggtggaaaatgaaaacagggtaaaaattggagattttgggttaaccaaagtcttgcca caagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtatgct ccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttggagtg gttctctatgaacttttcacatatattgagaagagtaaaagtcccccagcggaatttatg cgcatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactcttg aagaataatggaagattaccaagaccagatggatgcccagatgagatttatttgatcatg acagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagctcttcga gttgatcaaataagggacaacatggctggatga

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