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Ornithorhynchus anatinus (platypus): 100074305
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Entry
100074305 CDS
T01045
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa01521
EGFR tyrosine kinase inhibitor resistance
oaa04062
Chemokine signaling pathway
oaa04148
Efferocytosis
oaa04151
PI3K-Akt signaling pathway
oaa04217
Necroptosis
oaa04550
Signaling pathways regulating pluripotency of stem cells
oaa04630
JAK-STAT signaling pathway
oaa04658
Th1 and Th2 cell differentiation
oaa04659
Th17 cell differentiation
oaa04725
Cholinergic synapse
oaa04917
Prolactin signaling pathway
oaa04920
Adipocytokine signaling pathway
oaa04933
AGE-RAGE signaling pathway in diabetic complications
oaa04935
Growth hormone synthesis, secretion and action
oaa05140
Leishmaniasis
oaa05145
Toxoplasmosis
oaa05152
Tuberculosis
oaa05161
Hepatitis B
oaa05164
Influenza A
oaa05167
Kaposi sarcoma-associated herpesvirus infection
oaa05168
Herpes simplex virus 1 infection
oaa05200
Pathways in cancer
oaa05207
Chemical carcinogenesis - receptor activation
oaa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
oaa05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
100074305 (JAK2)
04151 PI3K-Akt signaling pathway
100074305 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
100074305 (JAK2)
09143 Cell growth and death
04217 Necroptosis
100074305 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
100074305 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
100074305 (JAK2)
04659 Th17 cell differentiation
100074305 (JAK2)
04062 Chemokine signaling pathway
100074305 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
100074305 (JAK2)
04917 Prolactin signaling pathway
100074305 (JAK2)
04935 Growth hormone synthesis, secretion and action
100074305 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
100074305 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100074305 (JAK2)
05207 Chemical carcinogenesis - receptor activation
100074305 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100074305 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
100074305 (JAK2)
05164 Influenza A
100074305 (JAK2)
05168 Herpes simplex virus 1 infection
100074305 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
100074305 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
100074305 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
100074305 (JAK2)
05140 Leishmaniasis
100074305 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100074305 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100074305 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100074305 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oaa01001
]
100074305 (JAK2)
Enzymes [BR:
oaa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
100074305 (JAK2)
Protein kinases [BR:
oaa01001
]
Non-receptor tyrosine kinases
JAK family [OT]
100074305 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
ABC1
FERM_C_FAK1
RIO1
Kinase-like
Motif
Other DBs
NCBI-GeneID:
100074305
NCBI-ProteinID:
XP_028912209
Ensembl:
ENSOANG00000010092
LinkDB
All DBs
Position
X5:complement(52237628..52413815)
Genome browser
AA seq
1129 aa
AA seq
DB search
MACLTLTEMEGTATSTAHQNGDVPGNDNAVKQIEPFLQVYLYHFLGKAEGDYLQFPAGEH
IAEEICVAASKACGVTPVYHNMFALMCETDRTWYPPNHVFHIDESTKHTVLYRIRFYFPH
WYCNGDKRAYRHGISRGSEAPLLDDYIMSYLFAQWRDDFVHGWIKVPVTHETQEECLGMA
VLDMMRIAKEKDQTPLAIYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFSQ
CKATARNLKLKYLINLETLQSAFYSEKFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK
HKESETLAEQDLQTYCDFPDIIDVSIKQANQEDSTESRVVTIHKQDSKNLEIEFLSLKEA
LSFVSLIDGYYRLTADAHHYLCKEVAPPTVLKNIQSNCHGPISMEFAISKLKKAGNQTGL
YVLRCSPKDFNKYFLTFAVEREHVMDYKHCLITKNENSEYNLSGTKKSFGNLKDLLNCYQ
METVRSDSIIFQFTKCCPPKPKDKSNLLVFRSNGISDVLTSPTLQRHNNVNQMVFHKIRN
EDLTFNESLGQGTFTKIFKGVRKEIGDYGLHQTEVLLKVLDKAHRNYSESFFEAASMMSQ
LSYKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMHF
LEEKNLIHGNVCSKNILLIREEDRKSGNPPFIKLSDPGISITVLPKDILLERIPWVPPEC
IENPKNLSLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELANL
INNCMEFEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQ
FEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILK
SLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLQYTSQICKG
MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP
ESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK
NNGRLPRPEGCPDAIYSIMTECWNNNLSQRPSFRELTVRVDRIRDNMGG
NT seq
3390 nt
NT seq
+upstream
nt +downstream
nt
atggcttgcctcaccttgacagagatggagggaactgccacatctaccgctcatcagaat
ggcgatgtccccgggaacgataatgctgtgaagcaaatagagccgtttcttcaggtctat
ctttaccacttcctgggaaaggctgagggagattacttacagtttccagccggggagcat
attgctgaagagatttgtgtggctgctagtaaagcttgtggtgtcacacctgtgtatcat
aacatgtttgctctaatgtgtgagacagacaggacctggtatcctcccaaccacgtcttc
catatagacgagtcaaccaagcacaccgtcctgtaccgaataaggttttactttcctcac
tggtattgtaatggagataagcgagcctaccgacatgggatttctcgaggctctgaggcc
cctcttcttgatgattatatcatgtcttacctctttgctcagtggagagatgactttgtt
catggttggataaaggtgcctgtaactcatgaaacacaggaagaatgtcttgggatggcg
gtcctggatatgatgagaatagctaaggaaaaagaccaaacccccttggccatctataac
tctatcagctacaagactttcttaccaaaatgtgttcgagcaaagattcaagactatcac
attttgacgcgaaagcgaataaggtacaggttccgcagatttattcagcaattcagccag
tgcaaagctactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag
tctgccttctactcagaaaaatttgaagtaaaagagcctggcagaggtccttcaggtgag
gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa
cataaagaaagtgagacactggcagaacaggatttacaaacatactgtgactttcctgat
attatcgatgtgagcattaaacaagcaaaccaagaagactctactgagagtagggtggta
actattcataagcaagacagcaagaatttggaaattgaatttctctccttaaaagaagct
ctgtcttttgtgtcgctgatcgatgggtattacagattgactgcagatgcacaccattac
ctctgtaaagaagtcgcacccccgacagtgcttaaaaatatccaaagcaattgtcacggg
cccatttcaatggaatttgccatcagtaaactgaagaaagcgggtaaccaaacgggcctc
tatgtccttcgctgcagtcctaaagactttaataaatacttcctcacctttgctgttgag
cgggaacatgtcatggattacaaacattgcttgattactaaaaatgagaacagcgaatac
aatctcagtggaactaagaagagctttggtaaccttaaagatcttctgaactgctatcag
atggaaactgttcgctcggacagcatcattttccagtttaccaagtgttgcccccctaaa
cccaaagataaatctaatctcttagtcttcaggagcaatggcatttctgacgtacttaca
tcacccacattgcagagacacaataatgtaaaccagatggtttttcacaaaatcagaaat
gaagatttgacgtttaacgaaagtctgggacaaggtacctttaccaagattttcaagggt
gtaaggaaagaaataggagactacggtctccatcaaacagaagtccttttaaaagttctg
gataaagcccacagaaactattcagagtctttttttgaagcagcaagcatgatgagccaa
ctttcttacaagcaccttgtattaaattatggagtctgtgtctgtggagaggaaaatatc
ctggttcaagagtttgtcaaatttggatcactggacacatacctgaagaaaaacaagaat
tctatcaatattttgtggaagttggaagtggccaaacaattggcatgggccatgcatttt
ctagaggaaaaaaatctcattcatgggaatgtgtgttcaaaaaatattttacttatcagg
gaagaggacaggaaatcaggaaaccctcctttcatcaaactcagcgatccgggcattagt
attacagttttgccgaaagacattcttctagagagaataccatgggttccacctgaatgc
attgaaaaccccaaaaatctaagcttggcaacagataaatggagttttggaaccactctg
tgggaaatctgcagtggaggagacaaaccactgagtgcacttgattctcaaagaaagcta
cagttttacgaagacaggcaccaacttcctgcaccaaaatggacagaattagcaaatctt
atcaacaactgtatggaatttgaaccagatttcagaccttctttcagagccatcatacgg
gatctcaacagtttgttcactccagattatgaacttttaacagaaaatgacatgttaccc
aacatgagaattggtgctcttggattttctggtgcatttgaagacagggaccccacacag
tttgaagagagacaccttaaattcctacaacagctcggcaagggtaattttggcagtgtg
gagatgtgccgatacgaccccctgcaagacaatactggtgaggtggtagctgtgaaaaag
cttcagcacagcactgaagagcacttgcgagattttgaaagagaaattgaaattcttaaa
tccctgcagcatgataacattgtcaaatacaagggagtctgctatagtgccggtcgtcgt
aatctgaggctgatcatggaatatttgccctacggaagtttacgtgattatctccaaaag
cataaggaaaggctggatcataagaagctattacagtacacgtctcagatatgcaagggc
atggagtatcttggaacaaagagatacatccatagggatctggccacaagaaatatctta
gtggagaatgagaacagagttaaaattggagattttggattgacaaaagtcctgccacaa
gataaggaatattacaaagtgaaagaacctggagaaagtcccatattctggtatgctccg
gaatctctgacagagagcaagttttccgtagcctcagatgtctggagttttggagtggtt
ctgtatgaactcttcacatatattgagaaaagcaaaagtcctccagcggaattcatgcga
atgattggcaatgacaaacaaggacagatgattgtattccatttgatagaacttttgaag
aataacggacggcttccaagaccagagggctgtcccgatgcgatttattctataatgacg
gagtgctggaacaacaacctaagccagcgcccctccttcagggagctcactgttcgagtg
gatcgcatccgggacaacatgggtggatga
DBGET
integrated database retrieval system