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Ornithorhynchus anatinus (platypus): 100086380
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Entry
100086380 CDS
T01045
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa01521
EGFR tyrosine kinase inhibitor resistance
oaa01522
Endocrine resistance
oaa04010
MAPK signaling pathway
oaa04012
ErbB signaling pathway
oaa04015
Rap1 signaling pathway
oaa04024
cAMP signaling pathway
oaa04062
Chemokine signaling pathway
oaa04068
FoxO signaling pathway
oaa04150
mTOR signaling pathway
oaa04270
Vascular smooth muscle contraction
oaa04510
Focal adhesion
oaa04650
Natural killer cell mediated cytotoxicity
oaa04720
Long-term potentiation
oaa04722
Neurotrophin signaling pathway
oaa04726
Serotonergic synapse
oaa04730
Long-term depression
oaa04810
Regulation of actin cytoskeleton
oaa04910
Insulin signaling pathway
oaa04914
Progesterone-mediated oocyte maturation
oaa04928
Parathyroid hormone synthesis, secretion and action
oaa04934
Cushing syndrome
oaa05010
Alzheimer disease
oaa05022
Pathways of neurodegeneration - multiple diseases
oaa05034
Alcoholism
oaa05160
Hepatitis C
oaa05161
Hepatitis B
oaa05200
Pathways in cancer
oaa05205
Proteoglycans in cancer
oaa05208
Chemical carcinogenesis - reactive oxygen species
oaa05210
Colorectal cancer
oaa05211
Renal cell carcinoma
oaa05212
Pancreatic cancer
oaa05213
Endometrial cancer
oaa05214
Glioma
oaa05215
Prostate cancer
oaa05216
Thyroid cancer
oaa05218
Melanoma
oaa05219
Bladder cancer
oaa05220
Chronic myeloid leukemia
oaa05221
Acute myeloid leukemia
oaa05223
Non-small cell lung cancer
oaa05224
Breast cancer
oaa05225
Hepatocellular carcinoma
oaa05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100086380 (BRAF)
04012 ErbB signaling pathway
100086380 (BRAF)
04015 Rap1 signaling pathway
100086380 (BRAF)
04068 FoxO signaling pathway
100086380 (BRAF)
04024 cAMP signaling pathway
100086380 (BRAF)
04150 mTOR signaling pathway
100086380 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
100086380 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100086380 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100086380 (BRAF)
04062 Chemokine signaling pathway
100086380 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
100086380 (BRAF)
04914 Progesterone-mediated oocyte maturation
100086380 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
100086380 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100086380 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
100086380 (BRAF)
04720 Long-term potentiation
100086380 (BRAF)
04730 Long-term depression
100086380 (BRAF)
04722 Neurotrophin signaling pathway
100086380 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100086380 (BRAF)
05205 Proteoglycans in cancer
100086380 (BRAF)
05208 Chemical carcinogenesis - reactive oxygen species
100086380 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
100086380 (BRAF)
05212 Pancreatic cancer
100086380 (BRAF)
05225 Hepatocellular carcinoma
100086380 (BRAF)
05226 Gastric cancer
100086380 (BRAF)
05214 Glioma
100086380 (BRAF)
05216 Thyroid cancer
100086380 (BRAF)
05221 Acute myeloid leukemia
100086380 (BRAF)
05220 Chronic myeloid leukemia
100086380 (BRAF)
05218 Melanoma
100086380 (BRAF)
05211 Renal cell carcinoma
100086380 (BRAF)
05219 Bladder cancer
100086380 (BRAF)
05215 Prostate cancer
100086380 (BRAF)
05213 Endometrial cancer
100086380 (BRAF)
05224 Breast cancer
100086380 (BRAF)
05223 Non-small cell lung cancer
100086380 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
100086380 (BRAF)
05160 Hepatitis C
100086380 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100086380 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
100086380 (BRAF)
09165 Substance dependence
05034 Alcoholism
100086380 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100086380 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100086380 (BRAF)
01522 Endocrine resistance
100086380 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oaa01001
]
100086380 (BRAF)
Enzymes [BR:
oaa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100086380 (BRAF)
Protein kinases [BR:
oaa01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100086380 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
FliD_N
Motif
Other DBs
NCBI-GeneID:
100086380
NCBI-ProteinID:
XP_028929058
Ensembl:
ENSOANG00000013389
LinkDB
All DBs
Position
10:51833914..51952194
Genome browser
AA seq
787 aa
AA seq
DB search
MEPEAAAAGAASSASSSSSAEPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYL
EAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSSSSSSLSVAPSSLSVFQ
NPTDAARGNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYR
IQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF
RCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLGETTLTSGSSPS
ATPSDSIGPPIVASPSPSKSIPIPQSFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNI
DDLIRDQGLRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLS
ATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITV
GQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGY
STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS
NNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDV
YAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKK
KRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGG
YGGFPVH
NT seq
2364 nt
NT seq
+upstream
nt +downstream
nt
atggagcccgaggccgccgccgccggcgcggcctcctcggcgtcgtcctcctcatcggcc
gagcccgccatccccgaggaggtgtggaatatcaaacagatgattaaactgacccaggaa
cacatagaggccctgctggacaagttcggaggagagcacaacccaccatcgatctacctg
gaggcctacgaggagtacaccagcaagctggacgccctgcagcagagagagcagcagctg
ctggagtccctggggaacgggaccgacttctccgtttccagctccgcttcgacggacacc
gtcacgtcctcttcgtcgtccagcctctcggtggccccttcgtccctctcggtctttcag
aaccccaccgacgcggcccggggtaaccccaagtctccgcagaagccgatagtccgcgtc
ttcctcccgaacaagcagaggacggtggtgccggcaagatgtggggtgacggtccgggac
agcctaaagaaagccctgatgatgcgaggtctcatccccgagtgctgtgccgtttacaga
attcaggatggagagaagaagccgatcggctgggacacggacatctcttggctcacggga
gaagagttgcacgtggaagttttggagaacgttccgcttaccacccacaattttgtacgg
aagacattctttactttagcattctgcgacttttgtagaaagctgcttttccagggtttc
cgctgccaaacgtgtggctacaaatttcaccagcgctgtagtacggaggtgccgctgatg
tgtgttaattacgaccagcttgatttgctgtttgtctccaagttctttgaacaccaccca
ataccacaggaggaggcctccttaggagagaccacccttacgtcgggatcatccccttca
gccaccccctcagattctattggacctccaattgttgccagcccatcaccttcaaaatcc
attccaattccacagtccttccggccggcagatgaagaccatcggaatcagtttgggcaa
cgggaccgctcctcttcggccccaaacgttcacataaacacaatagagcctgtcaatatt
gacgacttgattagagaccaagggttacgtggggatggagcccctttgaaccagctgatg
cgctgccttcggaaataccaatcccggactcccagccccctcctccattctgtccccagt
gaaatagtgtttgattttgagcctggcccagtgttcagagggtcaactacaggcttgtct
gccacccctcctgcctccttgcccggatctctgaccaatgtaaaagcgttacagaaatct
ccaggacctcagcgggagaggaagtcttcgtcgtcctcagaagacaggaatagaatgaaa
accttaggtcgccgggactcgagtgacgactgggagattcccgacgggcagatcacagtt
ggacagaggatagggtcagggtcctttggaactgtctataagggaaaatggcacggtgat
gtggcagtgaaaatgttgaatgtgacagcccccacacctcagcagttacaggccttcaaa
aatgaagtaggagtgctcaggaaaacacgacatgtgaatatcctcctcttcatgggctat
tccacaaagccccagttggcgatcgtgacccagtggtgtgaaggctccagcttatatcac
catctccacatcatcgagaccaaatttgagatgatcaagctgatagacatcgcccggcag
actgcacaaggcatggactacttgcacgccaagtcaatcatccacagagacctcaagagt
aataatatatttcttcatgaagacctcacagtcaaaataggggatttcggtctagctaca
gtgaaatctcgatggagtgggtcccatcagttcgaacagttgtccggttccattttgtgg
atggccccggaggtaattagaatgcaagataaaaacccatatagctttcagtcggacgtg
tacgcgtttgggattgttctgtatgaactgatgacaggccagttgccgtactcgaacatc
aacaacagggaccagatcatttttatggtgggacggggctacctgtctccagacctcagt
aaagtgcggagtaattgtccaaaagccatgaagagattaatggcggagtgcctgaagaag
aaaagagacgagaggccactctttccacagattcttgcctccattgagctcctggcccgg
tcgttgccaaaaatccaccgcagtgcatctgagccctcgttgaaccgggccggcttccaa
acggaggattttagtctgtacgcgtgcgcctctcccaaaacgcccatccaggcaggggga
tacggtgggtttcccgttcactga
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