Ovis aries (sheep): 101113909 Help Entry 101113909         CDS       T03117                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism oas  Ovis aries (sheep) Pathway oas01521   EGFR tyrosine kinase inhibitor resistance oas04062   Chemokine signaling pathway oas04148   Efferocytosis oas04151   PI3K-Akt signaling pathway oas04217   Necroptosis oas04550   Signaling pathways regulating pluripotency of stem cells oas04630   JAK-STAT signaling pathway oas04658   Th1 and Th2 cell differentiation oas04659   Th17 cell differentiation oas04725   Cholinergic synapse oas04917   Prolactin signaling pathway oas04920   Adipocytokine signaling pathway oas04933   AGE-RAGE signaling pathway in diabetic complications oas04935   Growth hormone synthesis, secretion and action oas05140   Leishmaniasis oas05145   Toxoplasmosis oas05152   Tuberculosis oas05161   Hepatitis B oas05164   Influenza A oas05167   Kaposi sarcoma-associated herpesvirus infection oas05168   Herpes simplex virus 1 infection oas05200   Pathways in cancer oas05207   Chemical carcinogenesis - receptor activation oas05235   PD-L1 expression and PD-1 checkpoint pathway in cancer oas05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:oas00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101113909 (JAK2)    04151 PI3K-Akt signaling pathway     101113909 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     101113909 (JAK2)   09143 Cell growth and death    04217 Necroptosis     101113909 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101113909 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101113909 (JAK2)    04659 Th17 cell differentiation     101113909 (JAK2)    04062 Chemokine signaling pathway     101113909 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     101113909 (JAK2)    04917 Prolactin signaling pathway     101113909 (JAK2)    04935 Growth hormone synthesis, secretion and action     101113909 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     101113909 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101113909 (JAK2)    05207 Chemical carcinogenesis - receptor activation     101113909 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101113909 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     101113909 (JAK2)    05164 Influenza A     101113909 (JAK2)    05168 Herpes simplex virus 1 infection     101113909 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     101113909 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     101113909 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101113909 (JAK2)    05140 Leishmaniasis     101113909 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101113909 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101113909 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101113909 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oas01001]     101113909 (JAK2) Enzymes [BR:oas01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101113909 (JAK2) Protein kinases [BR:oas01001]  Non-receptor tyrosine kinases   JAK family [OT]    101113909 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  101113909 NCBI-ProteinID:  XP_004004406 LinkDB All DBs Position 2:73329371..73445358 Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGKAEEDYLKFPTG EYVAEEICIAASKACGITPVYYSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFHKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCAKNVLLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtgcat cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttgggaaagctgaggaggattatctgaagtttccaactgga gagtatgttgctgaagagatttgtattgctgcttctaaagcttgtggaatcacacctgta tattatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttt ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggcgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaagtacccgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaagaatcaaacgccactggacatc tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagaaattgaacttaagtcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact ggactctatgtacttcgatgcagtcccaaggactttcataaatattttctgacttttgct gttgagcgagagaatgttattgaatataagcactgtttgattacaaaaaatgaaaatgga gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc taccagatggaaactgttcgctcggacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtgtttctgatgta ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt aaaggtataagaagagaaataggagactatggtcagctgcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggaatttgtaaaatttggatcactagatacatatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatgttctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt accacattgtgggaaatctgtagtggaggagataagccgctgagtgctttggattctcaa agaaaactacaattttatgaagataggcaccagcttcctgcaccaaagtggacagaatta gcaaatcttattaataattgcatggattatgaaccagattttagaccttctttcagagcc attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgagaataggtgccctaggattttctggtgcttttgaagaccgagac cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct gtgaaaaagctccagcacagtactgaagagcacctcagagactttgaaagagaaattgaa atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgttacagtgct ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtacacatctcagata tgcaagggcatggaatatcttggtacaaaaaggtatatccacagggatctggcaacaagg aatatactagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt ggagtggttctgtatgaacttttcacatatattgagaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgatcgtgtttcatttgatagaa ctcctaaagaataatggaagattaccgagaccagatggatgcccagatgagatttacgtg attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca gttcgagttgatcaaataagggacaacatgactggatga

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