Puma concolor (puma): 112868696 Help Entry 112868696         CDS       T08890                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism pcoo  Puma concolor (puma) Pathway pcoo01521   EGFR tyrosine kinase inhibitor resistance pcoo04062   Chemokine signaling pathway pcoo04148   Efferocytosis pcoo04151   PI3K-Akt signaling pathway pcoo04217   Necroptosis pcoo04550   Signaling pathways regulating pluripotency of stem cells pcoo04630   JAK-STAT signaling pathway pcoo04658   Th1 and Th2 cell differentiation pcoo04659   Th17 cell differentiation pcoo04725   Cholinergic synapse pcoo04917   Prolactin signaling pathway pcoo04920   Adipocytokine signaling pathway pcoo04933   AGE-RAGE signaling pathway in diabetic complications pcoo04935   Growth hormone synthesis, secretion and action pcoo05140   Leishmaniasis pcoo05145   Toxoplasmosis pcoo05152   Tuberculosis pcoo05161   Hepatitis B pcoo05164   Influenza A pcoo05167   Kaposi sarcoma-associated herpesvirus infection pcoo05168   Herpes simplex virus 1 infection pcoo05200   Pathways in cancer pcoo05207   Chemical carcinogenesis - receptor activation pcoo05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pcoo05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     112868696 (JAK2)    04151 PI3K-Akt signaling pathway     112868696 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     112868696 (JAK2)   09143 Cell growth and death    04217 Necroptosis     112868696 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     112868696 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     112868696 (JAK2)    04659 Th17 cell differentiation     112868696 (JAK2)    04062 Chemokine signaling pathway     112868696 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     112868696 (JAK2)    04917 Prolactin signaling pathway     112868696 (JAK2)    04935 Growth hormone synthesis, secretion and action     112868696 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     112868696 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112868696 (JAK2)    05207 Chemical carcinogenesis - receptor activation     112868696 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     112868696 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     112868696 (JAK2)    05164 Influenza A     112868696 (JAK2)    05168 Herpes simplex virus 1 infection     112868696 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     112868696 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     112868696 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     112868696 (JAK2)    05140 Leishmaniasis     112868696 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     112868696 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     112868696 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     112868696 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcoo01001]     112868696 (JAK2) Enzymes [BR:pcoo01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      112868696 (JAK2) Protein kinases [BR:pcoo01001]  Non-receptor tyrosine kinases   JAK family [OT]    112868696 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  112868696 NCBI-ProteinID:  XP_025787452 LinkDB All DBs Position Unknown AA seq 1131 aa AA seqDB search MGMACLTMTEMEGVSVSPVHQNGDIPGNANSAKQIDPLLQVYLYHSLEKADGEYLKFPTG EYVAEEICVAASKACGITPVYHSMFALMSETERTWYPPNHVFHVDESTRHNILYRIRFYF PYWYCNGSNRTYRHGVSRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKIPVTHETQEECLG MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIVITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDVTIKQGNQEGSNESRIVTIHKQDGKNLEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERDNVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSISILWKLEVAKQLAWA MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNRIGTLGFSGAFEDRDP TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI LKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQIC KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY APESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL LKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG NT seq 3396 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttaccatgacggaaatggaaggagtgtctgtatctcctgtacat cagaatggtgatattcctggaaatgctaattctgcgaagcaaatagatccactcctacag gtgtatctttatcattctcttgagaaggctgatggagaatatctgaagtttccaactggg gagtatgttgcagaagaaatttgtgttgctgcttctaaagcttgtggaatcacgcccgtg tatcatagtatgtttgctttaatgagtgaaaccgaaaggacctggtatccgcccaaccat gtcttccatgtagatgaatcaaccaggcacaacatactctacagaataagattttacttt ccttactggtattgtaatggcagcaacagaacctatcggcatggagtgtctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaaataccggtgactcatgaaacgcaggaagaatgtcttgga atggcagtgttagatatgatgagactagccaaagagaaggatcaaaccccattggacatc tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac tatcatattttgacaaggaagagaataaggtatagatttcgcagatttattgagcagttc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaaca cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattgtaataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt cctgatatcattgatgtgactattaaacaaggaaaccaagaaggctcaaatgaaagtaga attgtaactatccataagcaagatggtaaaaatctggaaattgaactaagctcattaaga gaagctttatcctttgtgtcattaattgatggctattacagattaaccgcggatgcacat cattacctctgtaaagaagtagctcctccgatggtgcttgaaaatatacaaagcaactgt catggcccgattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagact ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gtcgagcgagataatgtcatcgaatataagcattgtttgattacaaaaaatgagaatgga gaatacaacctcagtgggaccaagaagaacttcagtaatcttaaagatcttttgaattgc taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgcccc ccaaagttgaaagataaatcaaatcttctagtctttagaaccaatggcgtttctgatgta ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc agaaatgaagatttgatatttaatgaaagccttgggcaaggcacttttacaaaaattttt aaaggtgtaagaagagaagtaggagactatggtcaactgcatgaaacagaagttctttta aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaagcacttggttttaaattatggagtatgtgtctgtggagag gaaaatattctggttcaggagtttgtaaaatttggatcattagatacatacctgaaaaag aataaaaattctataagtatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaagcccttattcatgggaatgtgtgtgccaaaaatattctg cttatcagagaagaagacagaaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagacaagcctctgagtgctttggattctcaa agaaagctccagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc atcatacgagatcttaatagtttgtttactccagattacgagctattaacagaaaatgac atgttgccaaataggataggcacccttgggttttctggagcttttgaagaccgagacccg acacagtttgaagagagacacttgaaatttctacagcagcttggcaagggcaattttggc agtgtggagatgtgccggtatgaccctctacaagacaacactggggaggtggtggccgtg aagaagctccagcacagtactgaggagcacctgagagactttgaaagagaaattgaaatc cttaaatccctgcagcatgacaacattgtcaagtacaagggagtgtgctacagtgctggc cggcgtaatttaagattaattatggaatatttaccatatggaagtttacgagattatctc caaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgc aagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaggaat atattggtggagaatgaaaacagggttaaaattggagattttggtttaaccaaagtcttg ccacaagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtat gctccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttgga gtggttctgtatgaacttttcacatacatcgagaagagtaaaagtccaccagcggaattt atgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactc ctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttgatt atgactgaatgctggaacaataatgtaaatcagcgtccctcttttagagacctagctctt cgagttgatcaaataagggacaacatggctggatga

DBGET integrated database retrieval system