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Pteropus vampyrus (large flying fox): 105291659
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Entry
105291659 CDS
T07815
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
pvp
Pteropus vampyrus (large flying fox)
Pathway
pvp01521
EGFR tyrosine kinase inhibitor resistance
pvp01522
Endocrine resistance
pvp04010
MAPK signaling pathway
pvp04012
ErbB signaling pathway
pvp04015
Rap1 signaling pathway
pvp04024
cAMP signaling pathway
pvp04062
Chemokine signaling pathway
pvp04068
FoxO signaling pathway
pvp04150
mTOR signaling pathway
pvp04270
Vascular smooth muscle contraction
pvp04510
Focal adhesion
pvp04650
Natural killer cell mediated cytotoxicity
pvp04720
Long-term potentiation
pvp04722
Neurotrophin signaling pathway
pvp04726
Serotonergic synapse
pvp04730
Long-term depression
pvp04810
Regulation of actin cytoskeleton
pvp04910
Insulin signaling pathway
pvp04914
Progesterone-mediated oocyte maturation
pvp04928
Parathyroid hormone synthesis, secretion and action
pvp04934
Cushing syndrome
pvp05010
Alzheimer disease
pvp05022
Pathways of neurodegeneration - multiple diseases
pvp05034
Alcoholism
pvp05160
Hepatitis C
pvp05161
Hepatitis B
pvp05200
Pathways in cancer
pvp05205
Proteoglycans in cancer
pvp05208
Chemical carcinogenesis - reactive oxygen species
pvp05210
Colorectal cancer
pvp05211
Renal cell carcinoma
pvp05212
Pancreatic cancer
pvp05213
Endometrial cancer
pvp05214
Glioma
pvp05215
Prostate cancer
pvp05216
Thyroid cancer
pvp05218
Melanoma
pvp05219
Bladder cancer
pvp05220
Chronic myeloid leukemia
pvp05221
Acute myeloid leukemia
pvp05223
Non-small cell lung cancer
pvp05224
Breast cancer
pvp05225
Hepatocellular carcinoma
pvp05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
pvp00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
105291659 (BRAF)
04012 ErbB signaling pathway
105291659 (BRAF)
04015 Rap1 signaling pathway
105291659 (BRAF)
04068 FoxO signaling pathway
105291659 (BRAF)
04024 cAMP signaling pathway
105291659 (BRAF)
04150 mTOR signaling pathway
105291659 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
105291659 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
105291659 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
105291659 (BRAF)
04062 Chemokine signaling pathway
105291659 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
105291659 (BRAF)
04914 Progesterone-mediated oocyte maturation
105291659 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
105291659 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
105291659 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
105291659 (BRAF)
04720 Long-term potentiation
105291659 (BRAF)
04730 Long-term depression
105291659 (BRAF)
04722 Neurotrophin signaling pathway
105291659 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
105291659 (BRAF)
05205 Proteoglycans in cancer
105291659 (BRAF)
05208 Chemical carcinogenesis - reactive oxygen species
105291659 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
105291659 (BRAF)
05212 Pancreatic cancer
105291659 (BRAF)
05225 Hepatocellular carcinoma
105291659 (BRAF)
05226 Gastric cancer
105291659 (BRAF)
05214 Glioma
105291659 (BRAF)
05216 Thyroid cancer
105291659 (BRAF)
05221 Acute myeloid leukemia
105291659 (BRAF)
05220 Chronic myeloid leukemia
105291659 (BRAF)
05218 Melanoma
105291659 (BRAF)
05211 Renal cell carcinoma
105291659 (BRAF)
05219 Bladder cancer
105291659 (BRAF)
05215 Prostate cancer
105291659 (BRAF)
05213 Endometrial cancer
105291659 (BRAF)
05224 Breast cancer
105291659 (BRAF)
05223 Non-small cell lung cancer
105291659 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
105291659 (BRAF)
05160 Hepatitis C
105291659 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
105291659 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
105291659 (BRAF)
09165 Substance dependence
05034 Alcoholism
105291659 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
105291659 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
105291659 (BRAF)
01522 Endocrine resistance
105291659 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pvp01001
]
105291659 (BRAF)
Enzymes [BR:
pvp01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
105291659 (BRAF)
Protein kinases [BR:
pvp01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
105291659 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
C1_1
RBD
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
Kdo
Motif
Other DBs
NCBI-GeneID:
105291659
NCBI-ProteinID:
XP_023386037
UniProt:
A0A6P6CF47
LinkDB
All DBs
Position
Unknown
AA seq
581 aa
AA seq
DB search
MMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTL
AFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEA
SLAETTLTSGSSPSAPPSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSS
APNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE
RKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKML
NVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIE
TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS
GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI
IFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIH
RSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq
1746 nt
NT seq
+upstream
nt +downstream
nt
atgatgagaggtctaatcccagagtgctgtgccgtttacagaattcaagatggagagaag
aagccaattggctgggacaccgatatttcctggcttactggagaggagttacatgtagaa
gtgctggaaaatgttccacttacaacacacaactttgtacggaaaacttttttcacctta
gcattttgtgacttttgtcgaaagctgcttttccagggtttccgctgtcaaacatgtggt
tataaatttcaccagcgttgtagtacagaggttcctctgatgtgtgttaattatgaccaa
cttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggaggaggcc
tccctagcagagaccacccttacgtctggatcatccccttccgcacccccttccgattct
attgggccccaaattctcaccagtccgtctccttcaaaatccattccaattccacagcct
ttccgaccagcagatgaagatcatcgaaatcagtttggacaacgagaccggtcttcatca
gctccaaatgtgcatataaacacaatagagcctgtcaatattgatgacttgattagagac
caagggtttcgtagtgatggaggatcaaccacaggtttgtctgccaccccccctgcctca
ttacctggctcactcactaatgtgaaagcattgcagaaatctccaggacctcagcgggaa
cggaaatcatcttcttcctcagaagacaggaatcgaatgaaaacacttggtagacgggat
tcaagtgatgattgggagattcctgatgggcagatcacagtgggacaaagaattggatct
gggtcatttgggacagtctacaaaggaaagtggcatggtgatgtggcagtgaagatgttg
aatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtaggagtactc
aggaaaacgcgacatgtgaatatcctactcttcatgggctattcaacaaagccacagctg
gctattgttacccagtggtgtgagggctccagcttatatcaccacctccacatcattgag
accaaatttgagatgatcaaacttatagatattgcacggcagactgcacagggcatggat
tacttacacgccaagtcaatcatccacagagacctcaagagtaataatatatttcttcat
gaagacctcacagtaaaaataggtgactttggtctagccacagtgaaatctcgatggagt
gggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagtaatc
agaatgcaagataaaaacccatatagttttcagtcagatgtatatgcatttgggattgtt
ctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagggaccagata
atttttatggtgggacgaggatatctgtctccagatctcagtaaggtacgaagtaactgt
ccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaagagatgaaagacca
ctctttccccaaattctcgcctctattgagctgctggcccgctcattgccaaaaattcac
cgcagtgcatcagaaccctccttgaatcgggccggcttccaaacagaggattttagtcta
tatgcttgtgcttctccaaaaacacccatccaggcagggggatatggtgcgtttcctgtc
cactga
DBGET
integrated database retrieval system