Pteropus vampyrus (large flying fox): 105303192 Help Entry 105303192         CDS       T07815                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism pvp  Pteropus vampyrus (large flying fox) Pathway pvp01521   EGFR tyrosine kinase inhibitor resistance pvp04062   Chemokine signaling pathway pvp04148   Efferocytosis pvp04151   PI3K-Akt signaling pathway pvp04217   Necroptosis pvp04550   Signaling pathways regulating pluripotency of stem cells pvp04630   JAK-STAT signaling pathway pvp04658   Th1 and Th2 cell differentiation pvp04659   Th17 cell differentiation pvp04725   Cholinergic synapse pvp04917   Prolactin signaling pathway pvp04920   Adipocytokine signaling pathway pvp04933   AGE-RAGE signaling pathway in diabetic complications pvp04935   Growth hormone synthesis, secretion and action pvp05140   Leishmaniasis pvp05145   Toxoplasmosis pvp05152   Tuberculosis pvp05161   Hepatitis B pvp05164   Influenza A pvp05167   Kaposi sarcoma-associated herpesvirus infection pvp05168   Herpes simplex virus 1 infection pvp05200   Pathways in cancer pvp05207   Chemical carcinogenesis - receptor activation pvp05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pvp05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     105303192 (JAK2)    04151 PI3K-Akt signaling pathway     105303192 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     105303192 (JAK2)   09143 Cell growth and death    04217 Necroptosis     105303192 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     105303192 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     105303192 (JAK2)    04659 Th17 cell differentiation     105303192 (JAK2)    04062 Chemokine signaling pathway     105303192 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     105303192 (JAK2)    04917 Prolactin signaling pathway     105303192 (JAK2)    04935 Growth hormone synthesis, secretion and action     105303192 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     105303192 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105303192 (JAK2)    05207 Chemical carcinogenesis - receptor activation     105303192 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     105303192 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     105303192 (JAK2)    05164 Influenza A     105303192 (JAK2)    05168 Herpes simplex virus 1 infection     105303192 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     105303192 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     105303192 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     105303192 (JAK2)    05140 Leishmaniasis     105303192 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     105303192 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     105303192 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105303192 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pvp01001]     105303192 (JAK2) Enzymes [BR:pvp01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      105303192 (JAK2) Protein kinases [BR:pvp01001]  Non-receptor tyrosine kinases   JAK family [OT]    105303192 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2_1 FERM_F2 Jak1_Phl ABC1 FERM_C_FAK1 Kinase-like RIO1 Motif Other DBs NCBI-GeneID:  105303192 NCBI-ProteinID:  XP_023377030 UniProt:  A0A6P6BPS1 LinkDB All DBs Position Unknown AA seq 952 aa AA seqDB search MAVLDMMRIAKEKDQTPLDIYSSVSYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKRKESETLTEQDLQLYCDFPDIIDVSIKQANQEVSNESRIVTIHKQDGKNLEVELNSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCNPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLNGTKKNFSNLKDLLNC YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLLRHNNVNQMVFHKI RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLFHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKSLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRHLALRVDQIRDSMAG NT seq 2859 nt NT seq  +upstreamnt  +downstreamnt atggcagtgttagatatgatgagaatagctaaagaaaaggatcaaaccccactggacatc tatagttctgtcagctacaagacatttttaccaaaatgtgttcgagcaaagatccaagaa tatcatattttgacaaggaaaagaataagatacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacgtaaagaaagtgagacactgacagaacaggatttacagttatattgtgatttt cctgatattattgatgtcagtattaagcaggcaaaccaggaagtctcaaatgaaagcaga attgtcactatccataagcaagatggtaaaaatctggaagttgaacttaactcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattacctctgtaaagaagtagcgcctccaacggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgccatcagtaaactgaagaaagcaggtaatcagact ggactctatgtacttcgatgcaatcctaaggactttaataaatattttttgacttttgct gtagagcgagaaaatgtcattgaatataagcattgtttgattacaaaaaatgaaaacgga gaatacaacctaaacgggactaagaagaacttcagtaatcttaaagatcttttgaattgc taccagatggaaactgttcgctcagacaatataattttccagtttacgaaatgctgtccc ccaaagccaaaagataaatcaaaccttctagtctttagaaccaatggtatttctgatgta ccaacctcaccaacattactgaggcataataatgtgaaccaaatggtttttcacaaaatt agaaatgaagatttgatattcaatgaaagccttggccaaggcacttttacaaaaattttt aaaggtgtaagaagagaagttggagactatggtcaactgcatgaaacagaagtcctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagtatg atgagccagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggagtttgtgaaatttggatcattagacacatatttgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaaccctttttcatgggaatgtgtgcgccaaaaatattcta cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaggacattcttcaagagagaataccatgggtacca cctgaatgcattgaaaatcctaaaagtctaaacttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagataagcctctcagtgctttggattctcaa agaaaactacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc attatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgctaccaaatatgaggataggtgccctggggttttctggtgcttttgaagaccgagac cctacacagtttgaagagagacacttgaaatttctgcagcaactgggcaagggtaatttt gggagtgtggagatgtgccgctatgaccctctacaagacaacactggggaggtggtggct gtgaaaaagctccagcacagcactgaagagcacctcagagattttgaaagggaaattgaa atccttaaatctctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct ggccggcgtaacctaagattaattatggaatatttaccatatggaagtttacgagactat cttcaaaagcataaagaacggatagatcataaaaaacttctgcagtacacatctcaaata tgcaagggtatggagtatcttggtacgaaaaggtatatccacagggatctggcaacaagg aatatattggtggagaatgaaaacagagttaaaattggagattttgggttaaccaaagtc ttgccacaagacaaagaatactataaagtgaaagaacctggtgaaagtcccatattctgg tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagtttt ggagttgttctttatgaacttttcacatatattgagaagagtaaaagtcctccagcggaa ttcatgcgtatgattggcaatgacaaacaagggcagatgattgtatttcatttgatagaa ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatgta atcatgacagaatgctggaacaataatgtaaatcaacgcccctctttcagacacctcgct cttcgagttgatcaaataagggacagcatggctggataa

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