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Puma yagouaroundi (jaguarundi): 121028241
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Entry
121028241 CDS
T07555
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
pyu
Puma yagouaroundi (jaguarundi)
Pathway
pyu01521
EGFR tyrosine kinase inhibitor resistance
pyu01522
Endocrine resistance
pyu04010
MAPK signaling pathway
pyu04012
ErbB signaling pathway
pyu04015
Rap1 signaling pathway
pyu04024
cAMP signaling pathway
pyu04062
Chemokine signaling pathway
pyu04068
FoxO signaling pathway
pyu04150
mTOR signaling pathway
pyu04270
Vascular smooth muscle contraction
pyu04510
Focal adhesion
pyu04650
Natural killer cell mediated cytotoxicity
pyu04720
Long-term potentiation
pyu04722
Neurotrophin signaling pathway
pyu04726
Serotonergic synapse
pyu04730
Long-term depression
pyu04810
Regulation of actin cytoskeleton
pyu04910
Insulin signaling pathway
pyu04914
Progesterone-mediated oocyte maturation
pyu04928
Parathyroid hormone synthesis, secretion and action
pyu04934
Cushing syndrome
pyu05010
Alzheimer disease
pyu05022
Pathways of neurodegeneration - multiple diseases
pyu05034
Alcoholism
pyu05160
Hepatitis C
pyu05161
Hepatitis B
pyu05200
Pathways in cancer
pyu05205
Proteoglycans in cancer
pyu05208
Chemical carcinogenesis - reactive oxygen species
pyu05210
Colorectal cancer
pyu05211
Renal cell carcinoma
pyu05212
Pancreatic cancer
pyu05213
Endometrial cancer
pyu05214
Glioma
pyu05215
Prostate cancer
pyu05216
Thyroid cancer
pyu05218
Melanoma
pyu05219
Bladder cancer
pyu05220
Chronic myeloid leukemia
pyu05221
Acute myeloid leukemia
pyu05223
Non-small cell lung cancer
pyu05224
Breast cancer
pyu05225
Hepatocellular carcinoma
pyu05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
pyu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
121028241 (BRAF)
04012 ErbB signaling pathway
121028241 (BRAF)
04015 Rap1 signaling pathway
121028241 (BRAF)
04068 FoxO signaling pathway
121028241 (BRAF)
04024 cAMP signaling pathway
121028241 (BRAF)
04150 mTOR signaling pathway
121028241 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
121028241 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
121028241 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
121028241 (BRAF)
04062 Chemokine signaling pathway
121028241 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
121028241 (BRAF)
04914 Progesterone-mediated oocyte maturation
121028241 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
121028241 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
121028241 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
121028241 (BRAF)
04720 Long-term potentiation
121028241 (BRAF)
04730 Long-term depression
121028241 (BRAF)
04722 Neurotrophin signaling pathway
121028241 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
121028241 (BRAF)
05205 Proteoglycans in cancer
121028241 (BRAF)
05208 Chemical carcinogenesis - reactive oxygen species
121028241 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
121028241 (BRAF)
05212 Pancreatic cancer
121028241 (BRAF)
05225 Hepatocellular carcinoma
121028241 (BRAF)
05226 Gastric cancer
121028241 (BRAF)
05214 Glioma
121028241 (BRAF)
05216 Thyroid cancer
121028241 (BRAF)
05221 Acute myeloid leukemia
121028241 (BRAF)
05220 Chronic myeloid leukemia
121028241 (BRAF)
05218 Melanoma
121028241 (BRAF)
05211 Renal cell carcinoma
121028241 (BRAF)
05219 Bladder cancer
121028241 (BRAF)
05215 Prostate cancer
121028241 (BRAF)
05213 Endometrial cancer
121028241 (BRAF)
05224 Breast cancer
121028241 (BRAF)
05223 Non-small cell lung cancer
121028241 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
121028241 (BRAF)
05160 Hepatitis C
121028241 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
121028241 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
121028241 (BRAF)
09165 Substance dependence
05034 Alcoholism
121028241 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
121028241 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
121028241 (BRAF)
01522 Endocrine resistance
121028241 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pyu01001
]
121028241 (BRAF)
Enzymes [BR:
pyu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
121028241 (BRAF)
Protein kinases [BR:
pyu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
121028241 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
121028241
NCBI-ProteinID:
XP_040327713
LinkDB
All DBs
Position
Unknown
AA seq
781 aa
AA seq
DB search
MAALSGGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEA
LLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSS
SSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKK
ALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFF
TLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQE
EASIAETALTSGSSPSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRS
SSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQ
RERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHI
IETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR
WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQERSRRKYRLFNSGY
PWKILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAF
K
NT seq
2346 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggcggcggcggcggcggtggcgcggagcagggccaggctctgttc
aacggggacatggagcccgaagccggcgccgcggcctcttcggctgcggaccctgccatt
cccgaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcc
ctattggacaaatttggtggggagcataatccaccatcaatatatctagaggcctatgaa
gaatacaccagcaagctagatgccctccaacagagagaacaacagttattggaatccctg
gggaatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcc
tcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaaccccacagat
gtgtcacggagcaatcccaagtcaccacagaaacctatcgttagagtcttcctgcctaat
aaacagaggacagtggtacctgcaagatgtggagttacagtccgggacagtctaaagaaa
gctctgatgatgagaggtctaatccctgagtgctgtgctgtttacagaattcaggatgga
gagaagaaaccaattggctgggacactgatatctcctggctcaccggagaggaattgcat
gtagaagtgttggaaaatgttccacttacaactcacaactttgtacggaaaacgtttttc
accttagcattttgtgacttttgtcgaaagctgcttttccaaggttttcgctgtcaaacg
tgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattat
gaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggag
gaggcctccatagcagagactgccctaacgtctggatcgtccccttctgcgcccccctcc
gattctactgggccccaaattctcaccagtccgtctccttcaaaatccattccaattcca
cagcctttccgaccagcagatgaagatcatcgaaatcaatttggacagcgagaccggtcc
tcatcagctccaaatgtgcatataaatacaatagaacctgtcaatattgatgacttgatt
agagaccaggggtttcgtagtgatggaggatcaaccacaggcttgtctgccaccccccct
gcctcattgccgggctctctcactaatgtaaaagcattacagaaatctccagggcctcag
cgggaaaggaaatcttcttcatcctcagaagataggaatcgaatgaaaacacttggtaga
agggattcaagtgatgattgggagattcctgatgggcagatcacagtgggacagagaatt
ggatccgggtcatttgggacagtctacaagggaaagtggcatggtgatgtggcagtgaaa
atgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtagga
gtactcaggaaaactcggcatgtgaacatcctgctcttcatgggctattcaacaaagccc
cagctggctattgtcacccagtggtgtgagggctccagcttataccaccatctccacatc
atcgagaccaaattcgagatgatcaagctgatagatattgctcggcagactgcgcagggc
atggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatattttt
cttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcga
tggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaa
gtaattcgaatgcaagataaaaacccatatagctttcagtcagatgtatatgcatttggg
attgttctatatgaattgatgactggacagttaccttattcaaacatcaacaacagggac
cagataatttttatggtgggacgaggatatctttctccagatctcagtaaggtacgaagt
aactgtccgaaagccatgaagagattgatggcagagtgcctaaaaaagaaaagagatgag
aggccactgtttccccaagaaaggtccagaagaaagtatagactctttaacagtggttac
ccctggaagattcttgcctctattgagctgctggcccgctcattgccaaaaattcaccgc
agtgcatcagaaccctccttgaatcgggctggcttccagacagaggattttagtctctat
gcttgtgcttctccaaaaacacccatccaggcagggggatatggagaatttgcagccttc
aagtag
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integrated database retrieval system