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Rattus norvegicus (rat): 114486
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Entry
114486 CDS
T01003
Symbol
Braf
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X2
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno04010
MAPK signaling pathway
rno04012
ErbB signaling pathway
rno04015
Rap1 signaling pathway
rno04024
cAMP signaling pathway
rno04062
Chemokine signaling pathway
rno04068
FoxO signaling pathway
rno04150
mTOR signaling pathway
rno04270
Vascular smooth muscle contraction
rno04510
Focal adhesion
rno04650
Natural killer cell mediated cytotoxicity
rno04720
Long-term potentiation
rno04722
Neurotrophin signaling pathway
rno04726
Serotonergic synapse
rno04730
Long-term depression
rno04810
Regulation of actin cytoskeleton
rno04910
Insulin signaling pathway
rno04914
Progesterone-mediated oocyte maturation
rno04928
Parathyroid hormone synthesis, secretion and action
rno04934
Cushing syndrome
rno05010
Alzheimer disease
rno05022
Pathways of neurodegeneration - multiple diseases
rno05034
Alcoholism
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05208
Chemical carcinogenesis - reactive oxygen species
rno05210
Colorectal cancer
rno05211
Renal cell carcinoma
rno05212
Pancreatic cancer
rno05213
Endometrial cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05216
Thyroid cancer
rno05218
Melanoma
rno05219
Bladder cancer
rno05220
Chronic myeloid leukemia
rno05221
Acute myeloid leukemia
rno05223
Non-small cell lung cancer
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
rno05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
114486 (Braf)
04012 ErbB signaling pathway
114486 (Braf)
04015 Rap1 signaling pathway
114486 (Braf)
04068 FoxO signaling pathway
114486 (Braf)
04024 cAMP signaling pathway
114486 (Braf)
04150 mTOR signaling pathway
114486 (Braf)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
114486 (Braf)
09142 Cell motility
04810 Regulation of actin cytoskeleton
114486 (Braf)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
114486 (Braf)
04062 Chemokine signaling pathway
114486 (Braf)
09152 Endocrine system
04910 Insulin signaling pathway
114486 (Braf)
04914 Progesterone-mediated oocyte maturation
114486 (Braf)
04928 Parathyroid hormone synthesis, secretion and action
114486 (Braf)
09153 Circulatory system
04270 Vascular smooth muscle contraction
114486 (Braf)
09156 Nervous system
04726 Serotonergic synapse
114486 (Braf)
04720 Long-term potentiation
114486 (Braf)
04730 Long-term depression
114486 (Braf)
04722 Neurotrophin signaling pathway
114486 (Braf)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
114486 (Braf)
05205 Proteoglycans in cancer
114486 (Braf)
05208 Chemical carcinogenesis - reactive oxygen species
114486 (Braf)
09162 Cancer: specific types
05210 Colorectal cancer
114486 (Braf)
05212 Pancreatic cancer
114486 (Braf)
05225 Hepatocellular carcinoma
114486 (Braf)
05226 Gastric cancer
114486 (Braf)
05214 Glioma
114486 (Braf)
05216 Thyroid cancer
114486 (Braf)
05221 Acute myeloid leukemia
114486 (Braf)
05220 Chronic myeloid leukemia
114486 (Braf)
05218 Melanoma
114486 (Braf)
05211 Renal cell carcinoma
114486 (Braf)
05219 Bladder cancer
114486 (Braf)
05215 Prostate cancer
114486 (Braf)
05213 Endometrial cancer
114486 (Braf)
05224 Breast cancer
114486 (Braf)
05223 Non-small cell lung cancer
114486 (Braf)
09172 Infectious disease: viral
05161 Hepatitis B
114486 (Braf)
05160 Hepatitis C
114486 (Braf)
09164 Neurodegenerative disease
05010 Alzheimer disease
114486 (Braf)
05022 Pathways of neurodegeneration - multiple diseases
114486 (Braf)
09165 Substance dependence
05034 Alcoholism
114486 (Braf)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
114486 (Braf)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
114486 (Braf)
01522 Endocrine resistance
114486 (Braf)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
114486 (Braf)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
114486 (Braf)
Protein kinases [BR:
rno01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
114486 (Braf)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
114486
NCBI-ProteinID:
XP_006236419
RGD:
619908
Ensembl:
ENSRNOG00000010957
LinkDB
All DBs
Position
4:complement(69329772..69476931)
Genome browser
AA seq
825 aa
AA seq
DB search
MAALSGGGGSSSGGGGGGGGGGGGGGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIP
EEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLG
NGADFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQTPTDVSRNNPKSPQKPIVRVFLPNK
QRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHV
EVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYD
QLDLLFVSKFFEHHPVPQEEAFSAETTLPSGCSSAPPSDSIGPQILTSPSPSKSIPIPQP
FRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGAPLNQLMRCLRKY
QSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE
RKSSSSSSSTEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
KIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2478 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagtggcggcggtggcagcagcagcggtggcggtggcggcggcggcggc
ggcggtggtggcggcggcggcggcggcgccgaacagggacaggctctgttcaatggcgac
atggagccggaggccggcgctggcgccgcggcctcttcggccgcggacccggccattcct
gaagaggtgtggaatatcaagcaaatgattaagttgacacaggaacatatagaggcccta
ttggacaagtttggtggggagcataacccaccgtcaatatacctggaggcctatgaagag
tacaccagcaagctagatgcccttcagcagagagagcagcagctgttggaatccctgggt
aatggagcagacttttctgtttctagctctgcatcaatggacaccgttacatcttcctcc
tcttctagcctttcagtgctaccgtcatctctttcagtttttcaaactcccacagatgta
tcacggaacaaccccaagtcaccacagaaacctatcgttcgtgtcttcctgcccaacaaa
cagaggacagtggtgcccgcaagatgtggtgtaacggtccgagacagtctaaagaaagca
ctaatgatgaggggtctcatcccagagtgctgtgctgtttacagaattcaggacggagag
aagaaaccaattggctgggacactgacatttcctggcttactggagaggagctacatgtt
gaagtactagagaatgttcctctgacaacccacaacttcgtacggaaaacttttttcacc
ttagcattttgtgacttttgccgaaagctgcttttccagggtttccgctgtcaaacatgt
ggttataagtttcaccagcgttgtagtacagaggttccactgatgtgtgttaattatgac
caacttgatttgctgtttgtctccaagttctttgagcatcacccagtaccacaggaggag
gccttctcagcagagactacccttccatctggatgctcttccgcacccccctcagactct
attgggccccaaatcctcaccagtccatctccttcaaaatccattccaattccacagccc
ttccggccagcagatgaagatcatcgcaatcagtttgggcaacgagaccgctcctcctcc
gctcccaatgttcatataaacacaatcgaacctgtcaatattgatgatttgattagagac
caggggtttcgtggggatggagcccctttgaaccagctgatgcgctgtcttcggaaatac
caatcccggactcccagccccctcctccattctgtccccagtgaaatagtgtttgatttt
gagcctggcccagtgttcagagggtcaaccacaggcttgtcggccaccccacctgcctca
ttacctggctcactcactaacgtgaaagccttacagaaatctccaggacctcagcgggaa
aggaagtcctcctcctcctcctcctccacggaagacagaagtcggatgaaaacacttggt
agaagagattcaagtgatgattgggagattcctgatggacagattacagtgggacagaga
attggatctgggtcctttggaactgtctacaagggaaagtggcatggcgacgtggcagtg
aaaatgctgaatgtgacagcacccacacctcagcagttacaggccttcaaaaacgaagtc
ggagtactcaggaaaactcgacatgtgaacatcctccttttcatgggctattctacaaag
ccacagctggctattgttacacagtggtgtgaaggctccagcttatatcaccatctccac
atcattgagaccaaatttgagatgatcaaacttatagatattgcacggcagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatata
tttcttcatgaagacctcacggtaaaaataggtgactttggtttagccacagtgaagtcc
cgatggagtgggtcccatcagtttgaacagttgtctggatctattttgtggatggcaccc
gaagtaatcagaatgcaagataaaaacccatatagctttcagtcagacgtgtatgcattt
gggattgttctgtatgaactgatgactggtcagctaccttattcaaacatcaacaacagg
gatcagataatttttatggtgggacgaggatacctatctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaaagagac
gagagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattgcca
aaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaacagaagat
tttagtctgtatgcttgtgcttctccaaaaacacccatccaagcagggggatatggagaa
tttgcagccttcaagtag
DBGET
integrated database retrieval system