23andMe’s Post

"New findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting. The results demonstrate evidence of health benefits beyond weight loss, but also show that any potentially health-altering changes appear to occur only after three days without food." "Researchers followed 12 healthy volunteers taking part in a seven-day water-only fast. The volunteers were monitored closely on a daily basis to record changes in the levels of around 3,000 proteins in their blood before, during, and after the fast. By identifying which proteins are involved in the body’s response, the researchers could then predict potential health outcomes of prolonged fasting by integrating genetic information from large-scale studies. As expected, the researchers observed the body switching energy sources – from glucose to fat stored in the body – within the first two or three days of fasting. The volunteers lost an average of 5.7 kg of both fat mass and lean mass. After three days of eating after fasting, the weight stayed off – the loss of lean was almost completely reversed, but the fat mass stayed off." “Our findings have provided a basis for some age-old knowledge as to why fasting is used for certain conditions. While fasting may be beneficial for treating some conditions, often times, fasting won’t be an option to patients suffering from ill health. We hope that these findings can provide information about why fasting is beneficial in certain cases, which can then be used to develop treatments that patients are able to do", said Maik Pietzner, lead author of the study. Article published in Nature Metabolism: https://lnkd.in/d22Ra3g7 #health #chronicdisease #healthylifestyle #lifestylemedicine #obesity #weightloss #insulinresistance #diabetes #fattyliverdisease #metabolichealth #proteomics #computationalmedicine #bigdata #bigdataanalytics #intermittentfasting #calories https://lnkd.in/dtMCJspF

✨ Good news coffee lovers ✨ A recent genetic study suggests that caffeine may offer protective effects against obesity and joint diseases. This finding adds to the array of potential benefits associated with caffeine consumption beyond its commonly recognized effects on alertness and mood. The study, published in BMC Medicine, utilized a phenome-wide association study to investigate the health outcomes linked to genetic predictors of plasma caffeine levels. The analysis involved a large cohort of individuals of European descent and explored the relationship between caffeine intake and various health conditions, including obesity and joint diseases. Results from the study indicated that long-term caffeine use might help prevent weight gain and reduce the risk of inflammation and degeneration in the joints. The mechanisms through which caffeine exerts these effects are multifaceted. Caffeine is known to stimulate the central nervous system, which can increase metabolism and promote the breakdown of fat cells, thus aiding in weight management and reducing the risk of obesity. Additionally, caffeine has been shown to enhance physical performance and endurance during exercise, contributing to weight maintenance and supporting joint health. Furthermore, caffeine can suppress appetite, leading to reduced calorie intake and helping prevent weight gain and obesity. Finally, caffeine possesses anti-inflammatory properties that may alleviate symptoms of joint diseases by modulating inflammatory pathways, potentially offering protective effects against joint degeneration and pain. Overall, these findings suggest that moderate caffeine consumption, within recommended limits, may confer benefits beyond its immediate effects on alertness and mood, potentially contributing to overall health and well-being. As always, it's essential to consume caffeine in moderation and be mindful of individual tolerance levels and health considerations. #coffee #healthcare #OpenAirPartners #toptiptuesday

Studies suggest that coffee consumption may have beneficial effects on human health, including reducing the risk of certain chronic diseases like cancer and cardiovascular disease, and improving neurological conditions like Parkinson's and Alzheimer's. However, genetics may play a role in determining individual benefits. The CYP1A2 gene affects caffeine metabolism, which means that some people may not experience the same health benefits as others. Further studies should investigate the association between coffee consumption and health benefits in individuals with specific genetic profiles. Lastly, keep in mind there’s no single ‘wonder food’ so a balanced low carb, high protein, moderate healthy fat and wholefood diet approach will compliment any benefits from coffee consumption. Try our 14 day metabolism reset program Be Fit Food with intermittent fasting using coffee before midday, but atleast 90-120mins after waking (to clear the adenosine from the adenosine receptors for which caffeine binds) for exhibiting coffee beneficial neurotrophic effects. Moderation is key, using 1-3mg caffeine per kilo of body weight to avoid jitters and anxiety effects in those who can process caffeine well. Others who can’t process caffeine well, are less likely to enjoy its bitter taste so follow your instincts and avoid it altogether. Use code ‘caffeine10’ for 10% off the 14 day reset at Be Fit Food before 30th April 2024. Thanks Ticker news and the incredible host of this segment Mike Loder for speaking with me live today from overseas too. #coffee #healthbenefits #genetics #publichealth

Our food industry focuses on making money. How does it make money? By making you want more and more food. How does it do that? By starving your body and brain of nutrients and feeding you empty calories-->ultra-processed foods. This is why you can eat a whole bag of Cheetos but not a whole bag of kale. The Cheetos are just empty calories so the complex signaling in your gut tube doesn't get stimulated to tell you you're satisfied. You're not satisfied. You've not had any nutrition. So what is the result? You look for more food to eat. It's a vicious cycle! Eating more and more calories with no nutrition = brain is never signaled to stop craving more food = undernourished but gaining weight. It's horrible! There is no food in that food! This is why all the "obesity drugs" result in weight loss. They trick your brain into thinking you are full so you stop eating. But the weight loss doesn't last after you stop taking them because you haven't learned to eat nutrient-dense, satisfying foods that feed your body and brain. Please read this article!

#Simple But With Great Benefits: Intensive lifestyle changes impact on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease - A clinical study #Mysummary The study, led by Dr Dean Ornish, M.D. , involved 51 participants randomly assigned to either an intervention group or a control group. The intervention group (n=26) followed a comprehensive lifestyle program that included a whole-food, plant-based diet, exercise (30 min/day), stress management techniques (yoga, meditation, ..), and supplements (omega-3 fatty acids with curcumin, a multivitamin and minerals, coenzyme Q10, vitamin C, vitamin B12, magnesium L-threonate, Hericium erinaceus (Lion's Mane), and a Bifidobacterium probiotic.) After just 20 weeks, the researchers observed an improvement in the gut microbiome composition of the intervention group (p <0.0001), while the control group showed no significant changes. With an increase of Blautia and Eubacterium and a decrease of Prevotella and Turicibacter, among others. As a primary endpoint of the study, the lifestyle intervention not only improved the microbiome but also showed significant improvements in cognitive function and biomarkers related to Alzheimer's disease. Participants in the intervention group experienced improvements in tests measuring cognition, global impression of change, and clinical dementia rating, while the control group generally worsened. #Mythoughts Believe it or not, we are really getting closer to homing of the impact of the gut microbiome on multiple diseases including those that are hard to diagnose early and treat. HAPPY to hear your THOUGHTS and Stay POSITIVE! #Myinspiration "Vision is the art of seeing what is invisible to others." - Jonathan Swift Link to the paper here: https://lnkd.in/dv3u27qe #microbiome #nutrition #science #health #tech #pharma #probiotics

The ethanolic extract of Murraya koenigii (L) leaves demonstrates anti-obesity and hypoglycemic effects in rats subjected to a high-fat diet. This research illuminates the potential therapeutic benefits of this plant extract in addressing obesity-related complications, offering insights into its dual impact on weight management and glucose regulation. The observed effects highlight the significance of natural compounds in modulating metabolic pathways, presenting avenues for the development of botanical-based interventions against obesity and associated metabolic disorders. These findings contribute to the ongoing exploration of alternative approaches to combat the global health challenges posed by obesity and its metabolic repercussions. Obesity Management: Preliminary studies suggest that Murraya koenigii leaves may help inhibit adipogenesis, potentially assisting in weight management efforts. Glucose Regulation: Research indicates that these leaves could play a role in stabilizing glucose levels, offering promising benefits for those seeking natural approaches to blood sugar control. https://lnkd.in/did6QHaB #MetabolicHealth #MurrayaKoenigii #NaturalHealth #ObesityResearch #Diabetes #reseapro #reseaprojournal

Curious about your metabolic health? I’ve just published a blog on Medium exploring what it means to be metabolically healthy, how you can determine your own metabolic status, and practical steps to improve it. If you're interested in learning more about how your metabolism affects your overall well-being, I invite you to read my latest post. Check it out here: https://lnkd.in/gHqHUU-x Your health journey matters. Let’s discover the signs and solutions together! #MetabolicHealth #vizzhy #multiomic #omics #aiiinhealthcare #healthcareinnovation #metabolicsyndrome

Gut Microbiome and Obesity. Read the article. The gut microbiome plays a significant role in the development and management of obesity. Here's how it impacts obesity: ### Key Mechanisms 1. **Energy Harvesting**: Certain gut bacteria are more efficient at extracting energy from food, leading to increased calorie absorption and fat storage¹². 2. **Fat Storage**: The gut microbiome can influence the body's fat storage mechanisms. Dysbiosis, or an imbalance in gut bacteria, can promote fat accumulation¹². 3. **Inflammation**: An unhealthy gut microbiome can lead to chronic low-grade inflammation, which is associated with obesity and metabolic disorders¹². 4. **Insulin Resistance**: Dysbiosis can contribute to insulin resistance, a key factor in the development of obesity and type 2 diabetes¹². ### Impact on Obesity - **Altered Microbiome Composition**: Obese individuals often have a different gut microbiome composition compared to lean individuals. For example, they may have higher levels of Firmicutes and lower levels of Bacteroidetes¹². - **Metabolic Changes**: The altered gut microbiome in obesity can lead to enhanced energy extraction from food, increased lipogenesis (fat creation), and insulin resistance¹². ### Supporting a Healthy Gut Microbiome To support a healthy gut microbiome and potentially reduce the risk of obesity, consider incorporating the following foods into your diet: - **Probiotic-Rich Foods**: Yogurt, kefir, sauerkraut, kimchi, and miso¹. - **Prebiotic Foods**: Asparagus, garlic, onions, bananas, and apples¹. - **Fiber-Rich Foods**: Whole grains, legumes, nuts, and seeds¹. Maintaining a balanced diet rich in these foods can help promote a healthy gut microbiome and support overall metabolic health. Would you like more information on specific foods or recipes to support your gut health? ¹: [Mayo Clinic](https://lnkd.in/gPWUBAz9) ²: [Cambridge Core](https://lnkd.in/gu4HAMCT) Source: Conversation with Copilot, 6/8/2024 (1) Role of gut microbiota in obesity and the future of microbiota .... https://lnkd.in/gPWUBAz9. (2) The role of gut microbiome in obesity: a systematic review. https://lnkd.in/gu4HAMCT. (3) Gut Microbiome and Its Potential Role in Obesity. https://lnkd.in/giMVbeF5.

#ScienceCommunication | 🦠 In the quest for new approaches to combat obesity in Mexico, a promising area is the study of gut microbiota. Besides favoring the digestion and absorption of nutrients, microbiota can influence our body weight. 🔬 A study conducted at Tecnológico de Monterrey has revealed changes in the abundance of certain bacteria that regulate appetite and satiety, suggesting a close relationship between bacteria and body weight. This discovery underscores the importance of investigating not only bacteria but also fungi as an integral part of our microbiota. ✍️ Researcher and expert on gut microbiota Ricardo García Gambona explains more about the topic in this article.

Research surrounding the microbiome has been explosive in the past decade, and will only continue to emerge, providing novel implications for our health. Specific strains of microbiota have been shown to have specialized roles in the body, and a growing body of research suggests that Akkermansia, a strain of bacteria we have in the microbiome, is significant to our metabolic health. Read this article to explore the roles Akkermansia has in modulating this foundational aspect of our health. https://lnkd.in/gcrP29gz #plmievent #plmi #personalizedlifestylemedicine #integrativemedicine #integrativehealth #functionalmedicinedoctor #functionalmedicine #akkermansia #microbiome #metabolichealth #metabolism #bloodsugar #healthyweight #healthandwellness