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JAK2 Janus kinase 2 [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100676652, updated on 6-Jun-2024

Summary

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Gene symbol
JAK2
Gene description
Janus kinase 2
See related
EnsemblRapid:ENSLAFG00000007471
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
human mouse all
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Genomic context

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See JAK2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 9 NC_087350.1 (118577068..118676172)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573508.1 (598475..693649, complement)

Chromosome 9 - NC_087350.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 3 Neighboring gene uncharacterized LOC135232325 Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene insulin like 6 Neighboring gene ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087350.1 Reference mLoxAfr1.hap2

    Range
    118577068..118676172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023539419.2 → XP_023395187.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    G3T029
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:36 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  2. XM_023539420.2 → XP_023395188.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    G3T029
    Related
    ENSLAFP00000006285.3, ENSLAFT00000007474.4
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:36 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  3. XM_010599992.3 → XP_010598294.1  tyrosine-protein kinase JAK2 isoform X1

    See identical proteins and their annotated locations for XP_010598294.1

    UniProtKB/TrEMBL
    G3T029
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:36 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  4. XM_023539417.2 → XP_023395185.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    G3T029
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:36 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  5. XM_023539418.2 → XP_023395186.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    G3T029
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:36 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  6. XM_023539416.2 → XP_023395184.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    G3T029
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:36 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  7. XM_064290594.1 → XP_064146664.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/TrEMBL
    G3T029

  8. XM_023539421.2 → XP_023395189.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/TrEMBL
    G3T029
    Conserved Domains (5) summary
    cd10379
    Location:303 → 399
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:1 → 187
    B41; Band 4.1 homologues
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:761 → 1044
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  9. XM_064290595.1 → XP_064146665.1  tyrosine-protein kinase JAK2 isoform X3

    UniProtKB/TrEMBL
    G3T029
Nucleotide Protein
Heading Accession and Version

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