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JAK2 Janus kinase 2 [ Microcaecilia unicolor ]

Gene ID: 115463367, updated on 11-Apr-2024

Summary

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Gene symbol
JAK2
Gene description
Janus kinase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Microcaecilia unicolor
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Gymnophiona; Siphonopidae; Microcaecilia
Orthologs
human mouse all
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Genomic context

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See JAK2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
25
Annotation release Status Assembly Chr Location
100 current aMicUni1.1 (GCF_901765095.1) 2 NC_044032.1 (233851717..234135658, complement)

Chromosome 2 - NC_044032.1Genomic Context describing neighboring genes Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene relaxin-3-like Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene transfer RNA glutamine (anticodon CUG)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_044032.1 Chromosome 2 Reference aMicUni1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multi-tissue transcriptomes of caecilian amphibians highlight incomplete knowledge of vertebrate gene families. Torres-Sánchez M, et al. DNA Res, 2019 Feb 1. PMID 30351380, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Microcaecilia unicolor Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference aMicUni1.1 Primary Assembly

Genomic

  1. NC_044032.1 Reference aMicUni1.1 Primary Assembly

    Range
    233851717..234135658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030193799.1 → XP_030049659.1  tyrosine-protein kinase JAK2

    UniProtKB/TrEMBL
    A0A6P7XG75
    Conserved Domains (6) summary
    cd10379
    Location:385 → 481
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:544 → 805
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:141 → 260
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:38 → 133
    FERM_F1; FERM F1 ubiquitin-like domain
    cl17171
    Location:265 → 385
    PH-like; Pleckstrin homology-like domain

  2. XM_030193800.1 → XP_030049660.1  tyrosine-protein kinase JAK2

    UniProtKB/TrEMBL
    A0A6P7XG75
    Conserved Domains (6) summary
    cd10379
    Location:385 → 481
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:544 → 805
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:141 → 260
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:38 → 133
    FERM_F1; FERM F1 ubiquitin-like domain
    cl17171
    Location:265 → 385
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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