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JAK2 Janus kinase 2 [ Acinonyx jubatus (cheetah) ]

Gene ID: 106968145, updated on 6-Jun-2024

Summary

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Gene symbol
JAK2
Gene description
Janus kinase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Acinonyx jubatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Acinonychinae; Acinonyx
Orthologs
human mouse all
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Genomic context

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See JAK2 in Genome Data Viewer
Location:
chromosome: D4
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_04 current VMU_Ajub_asm_v1.0 (GCF_027475565.1) D4 NC_069391.1 (86515967..86631508)

Chromosome D4 - NC_069391.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC113594254 Neighboring gene splicing factor 3B subunit 4-like Neighboring gene U6 spliceosomal RNA Neighboring gene 26S proteasome regulatory subunit 10B-like Neighboring gene insulin like 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_069391.1 Chromosome D4 Reference VMU_Ajub_asm_v1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027475565.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference VMU_Ajub_asm_v1.0

Genomic

  1. NC_069391.1 Reference VMU_Ajub_asm_v1.0

    Range
    86515967..86631508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015064485.3 → XP_014919971.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A6J1XWI1, A0A6J1XXE5
    Conserved Domains (6) summary
    cd10379
    Location:386 → 482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:843 → 1126
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  2. XM_027041152.2 → XP_026896953.1  tyrosine-protein kinase JAK2 isoform X3

    UniProtKB/TrEMBL
    A0A6J1XWI1, A0A6J1XWX7
    Conserved Domains (6) summary
    cd10379
    Location:386 → 482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:843 → 1019
    PKc_like; Protein Kinases, catalytic domain

  3. XM_027041150.2 → XP_026896951.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/TrEMBL
    A0A6J1XWI1, A0A6J1XWJ3
    Conserved Domains (6) summary
    cd10379
    Location:298 → 394
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:178 → 298
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:457 → 718
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:755 → 1038
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:116 → 173
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 118
    FERM_F1; FERM F1 ubiquitin-like domain

  4. XM_053205339.1 → XP_053061314.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A6J1XWI1, A0A6J1XXE5

  5. XM_027041149.2 → XP_026896950.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A6J1XWI1, A0A6J1XXE5
    Conserved Domains (6) summary
    cd10379
    Location:386 → 482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:843 → 1126
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  6. XM_027041153.2 → XP_026896954.1  tyrosine-protein kinase JAK2 isoform X4

    UniProtKB/TrEMBL
    A0A6J1XWI1, A0A6J1XWW4
    Conserved Domains (5) summary
    cd10379
    Location:206 → 302
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:86 → 206
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:365 → 626
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:663 → 946
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:1 → 81
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain

  7. XM_053205340.1 → XP_053061315.1  tyrosine-protein kinase JAK2 isoform X5

Nucleotide Protein
Heading Accession and Version

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