Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp

Xiao-Hong Yan; Li-Ping Lin; Jian Ding; Yue-Wei Guo

doi:10.1016/j.bmcl.2007.01.095

Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp

Bioorg Med Chem Lett. 2007 May 1;17(9):2661-3. doi: 10.1016/j.bmcl.2007.01.095. Epub 2007 Feb 2.

Authors

Xiao-Hong Yan¹, Li-Ping Lin, Jian Ding, Yue-Wei Guo

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.

PMID: 17337188
DOI: 10.1016/j.bmcl.2007.01.095

Abstract

A new steroid with an uncommon 21-oic acid methyl ester moiety designated methyl spongoate (1) which exhibited potent cytotoxicity against BEL-7402 tumor cells in vitro has been isolated from the Sanya soft coral Spongodes sp. Its structure was determined by detailed interpretation of spectroscopic data and by comparison with related compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Chemistry, Pharmaceutical / methods*
Drug Design
Drug Screening Assays, Antitumor
Esters / chemistry
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Models, Chemical
Molecular Conformation
Spectrophotometry
Steroids / chemistry*
Steroids / pharmacology*

Substances

Antineoplastic Agents
Esters
Steroids
methyl spongoate