Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors--a review of the triketone chemistry story from a Syngenta perspective

Renaud Beaudegnies; Andrew J F Edmunds; Torquil E M Fraser; Roger G Hall; Timothy R Hawkes; Glynn Mitchell; Juergen Schaetzer; Sebastian Wendeborn; Jane Wibley

doi:10.1016/j.bmc.2009.03.015

Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors--a review of the triketone chemistry story from a Syngenta perspective

Bioorg Med Chem. 2009 Jun 15;17(12):4134-52. doi: 10.1016/j.bmc.2009.03.015. Epub 2009 Mar 14.

Authors

Renaud Beaudegnies¹, Andrew J F Edmunds, Torquil E M Fraser, Roger G Hall, Timothy R Hawkes, Glynn Mitchell, Juergen Schaetzer, Sebastian Wendeborn, Jane Wibley

Affiliation

¹ Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland.

PMID: 19349184
DOI: 10.1016/j.bmc.2009.03.015

Abstract

A review, outlining the origins and subsequent development of the triketone class of herbicidal 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors.

Publication types

Review

MeSH terms

4-Hydroxyphenylpyruvate Dioxygenase / antagonists & inhibitors*
4-Hydroxyphenylpyruvate Dioxygenase / metabolism
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Herbicides / chemical synthesis
Herbicides / chemistry*
Herbicides / pharmacology
Ketones / chemical synthesis
Ketones / chemistry*
Ketones / pharmacology
Structure-Activity Relationship

Substances

Enzyme Inhibitors
Herbicides
Ketones
4-Hydroxyphenylpyruvate Dioxygenase