New cytotoxic steroids from the leaves of Clerodendrum trichotomum

Rui-Lan Xu; Rui Wang; Lan Ding; Yan-Ping Shi

doi:10.1016/j.steroids.2013.03.002

New cytotoxic steroids from the leaves of Clerodendrum trichotomum

Steroids. 2013 Jul;78(7):711-6. doi: 10.1016/j.steroids.2013.03.002. Epub 2013 Apr 10.

Authors

Rui-Lan Xu¹, Rui Wang, Lan Ding, Yan-Ping Shi

Affiliation

¹ Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.

PMID: 23583601
DOI: 10.1016/j.steroids.2013.03.002

Abstract

A phytochemical investigation of the leaves of Clerodendrum trichotomum led to the isolation of five new (2-6) and two known (1 and 7) steroids, whose structures and relative configurations were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Steroids 2 and 5 exhibited moderate cytotoxicity in vitro against HeLa cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Clerodendrum / chemistry*
Molecular Structure
Plant Leaves / chemistry*
Steroids / chemistry*

Substances

Steroids