Abstract
The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.
MeSH terms
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Adult
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Antibodies, Viral / blood
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Blood Donors
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Child
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Contact Tracing
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Germany
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Hepatitis Antibodies / blood
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Hepatitis E / blood*
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Hepatitis E / transmission
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Hepatitis E / virology
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Hepatitis E virus / genetics
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Hepatitis E virus / immunology
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Hepatitis E virus / isolation & purification*
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Humans
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Immunoglobulin G / blood
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RNA, Viral / blood*
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RNA, Viral / genetics
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Retrospective Studies
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Reverse Transcriptase Polymerase Chain Reaction
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Transfusion Reaction*
Substances
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Antibodies, Viral
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Hepatitis Antibodies
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Immunoglobulin G
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RNA, Viral