Svoboda | Graniru | BBC Russia | Golosameriki | Facebook

Acute-onset chronic inflammatory demyelinating polyneuropathy after COVID-19 infection and subsequent ChAdOx1 nCoV-19 vaccination

BMJ Case Rep. 2021 Oct 4;14(10):e245816. doi: 10.1136/bcr-2021-245816.

Abstract

SARS-COV-2 predominantly results in a respiratory illness. However, it has also been associated with a wide range of neurological disorders including a broad range of immune neuropathies. These immune neuropathies associated with SARS-COV2 infection include Guillain-Barré syndrome (GBS), recurrent GBS and exacerbation of pre-existing chronic inflammatory demyelinating polyneuropathy (CIDP). We describe a case with acute-onset CIDP presenting with three relapses of demyelinating polyradiculoneuropathy, the third relapse occurring in the 8 week of illness following a previous COVID-19 infection and a recent COVID-19 vaccination with ChAdOx1 nCoV-19 and high COVID-19 antibody level. In our knowledge, this is the ever reported case of acute-onset CIDP associated with COVID-19 vaccine and high COVID-19 antibody level.

Keywords: COVID-19; peripheral nerve disease; vaccination/immunisation.

Publication types

  • Case Reports

MeSH terms

  • COVID-19 Vaccines
  • COVID-19*
  • ChAdOx1 nCoV-19
  • Guillain-Barre Syndrome* / etiology
  • Humans
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating* / drug therapy
  • RNA, Viral
  • SARS-CoV-2
  • Vaccination / adverse effects

Substances

  • COVID-19 Vaccines
  • RNA, Viral
  • ChAdOx1 nCoV-19