Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

New biomarker helps determine the optimal treatment for colon cancer

Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn't improve the chances of survival for every patient. A study published July 25th, 2024 in Cell Reports Medicine identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy.

27 Jul 2024

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

The development of innovative medicines is an expensive, time-consuming and risky business. On average, it usually takes at least a decade and billions of dollars to bring a new drug from project initiation to approval.

25 Jul 2024

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

New study helps better understand the pathology of fatty liver disease MASH

A new study brings researchers closer to better understanding the pathology of the fatty liver disease MASH, which stands for metabolic dysfunction-associated steatohepatitis.

24 Jul 2024

Comprehensive dataset from A4 study yields key insights about Alzheimer's disease

Data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) study, the first and largest clinical trial of pre-symptomatic Alzheimer's disease, is now widely available to researchers studying the condition.

24 Jul 2024

AI model Virchow outperforms clinical methods in cancer detection

In a recent study published in Nature Medicine, researchers demonstrated the use of the foundational model Virchow for computational analysis of pathological reports, prediction of biomarkers, and identification of cells across multiple cancer types. Virchow's pan-cancer model showed impressive accuracy, often outperforming clinical-grade models.

23 Jul 2024

Study investigates the link between an exposome score and metabolic health across childhood

The combined effect of environmental exposures and unhealthy lifestyle habits can affect children's cardiometabolic health in a way that exceeds their separate effects.

23 Jul 2024

Blood test may aid early detection of Parkinson's and guide treatment strategies

To date Parkinson's disease (PD) is diagnosed clinically and rather late in the course of the disease. There is an urgent need to find an objective, quantifiable biomarker for the diagnosis of this highly prevalent movement disorder. Researchers have now found initial evidence that a blood test to detect the alpha-synuclein protein is a viable, less invasive option to diagnose PD. The study appears in the Journal of Parkinson's Disease, published by IOS Press, now part of Sage.

23 Jul 2024

Concussions in retired rugby players linked to higher neurodegenerative disease biomarkers

A study in the International Journal of Molecular Sciences reveals that retired rugby players with a history of concussions exhibit significant differences in biomarkers associated with neurodegenerative diseases compared to non-contact sports participants.

21 Jul 2024

AI and imaging advances revolutionize multiple sclerosis diagnosis

A study in Translational Vision Science & Technology reveals that integrating AI with IR-SLO and OCT imaging improves the automated diagnosis and classification of multiple sclerosis.

21 Jul 2024

Harnessing ctDNA measurements for response assessment in metastatic castration resistant prostate cancer

A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "Using early on-treatment circulating tumor DNA measurements as response assessment in metastatic castration resistant prostate cancer."

18 Jul 2024

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells.

18 Jul 2024

Researchers develop an analytical tool that could lead to lead to noninvasive "liquid biopsies"

Biopsies are clinical tools commonly used to diagnose a variety of diseases or to monitor tissue for abnormal growth or even rejection of a transplant.

17 Jul 2024

Novel method enables RNA detection with Cas12 nucleases

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics.

17 Jul 2024

Concussion history in rugby players linked to higher levels of neurodegenerative disease biomarkers

Retired rugby players who have suffered multiple concussions have higher levels of certain proteins in their blood, which may make them more prone to developing diseases such as motor neurone disease (MND), according to a new study.

17 Jul 2024

Predicting Alzheimer's decline: New model offers personalized insights for patients

Researchers developed a model to predict cognitive decline in Alzheimer's patients using clinical and biomarker data, improving personalized treatment plans.

16 Jul 2024

Archaea: Unseen players in human microbiome and infectious diseases

Archaea, key players in the human microbiome, are linked to various diseases but their pathogenic potential remains speculative. This study highlights their role in conditions like periodontitis and gastrointestinal infections.

16 Jul 2024

Early detection of specific microRNAs may help predict preeclampsia in pregnant women

Preeclampsia (PE) is a significant contributor to the increase in maternal morbidity and mortality worldwide, with particularly alarming numbers in the United States, where it affects about 2–8% of pregnancies, resulting in premature birth with associated morbidities for their infants as well.

16 Jul 2024

What is the association of Mediterranean diet–based interventions with cardiometabolic biomarkers in children and adolescents?

Researchers reviewed and meta-analyzed the randomized clinical trials (RCTs) assessing the effects of Mediterranean diet -based interventions on cardiometabolic biomarkers in children and adolescents.

16 Jul 2024

Triad of immune cells key to successful cancer immunotherapy, study finds

There's a frustrating fact about today's immunotherapies for cancer. While sometimes they work beautifully -; completely eliminating or greatly reducing cancer in particular patients -; other times they don't work at all. It's a mystery.

15 Jul 2024

Biomarker News and Research

Further Reading

New biomarker helps determine the optimal treatment for colon cancer

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

New study helps better understand the pathology of fatty liver disease MASH

Comprehensive dataset from A4 study yields key insights about Alzheimer's disease

AI model Virchow outperforms clinical methods in cancer detection

Study investigates the link between an exposome score and metabolic health across childhood

Blood test may aid early detection of Parkinson's and guide treatment strategies

Concussions in retired rugby players linked to higher neurodegenerative disease biomarkers

AI and imaging advances revolutionize multiple sclerosis diagnosis

Harnessing ctDNA measurements for response assessment in metastatic castration resistant prostate cancer

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors

Researchers develop an analytical tool that could lead to lead to noninvasive "liquid biopsies"

Novel method enables RNA detection with Cas12 nucleases

Concussion history in rugby players linked to higher levels of neurodegenerative disease biomarkers

Predicting Alzheimer's decline: New model offers personalized insights for patients

Archaea: Unseen players in human microbiome and infectious diseases

Early detection of specific microRNAs may help predict preeclampsia in pregnant women

What is the association of Mediterranean diet–based interventions with cardiometabolic biomarkers in children and adolescents?

Triad of immune cells key to successful cancer immunotherapy, study finds

eBook: Cellular Senescence eBook

Revolutionizing hepatocyte count for researchers

E-Cigarettes and Ethanol: A forensic Perspective on Vaping

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