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Scientists map molecules within human brain for first time

Scientists investigating Alzheimer's disease have determined the structure of molecules within a human brain for the very first time.

12 Jul 2024

Study reveals how DDM1 protein suppresses 'jumping genes' in plants

International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of "jumping genes."

11 Jul 2024

Cryo-EM reveals structural dynamics of RNAP-DNA interactions during transcription initiation

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble, so that one exposed DNA strand can be copied into a complementary RNA strand.

10 Jul 2024

New study reveals how RNA polymerase opens the transcription bubble in real time

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA.

3 Jul 2024

NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine

A Phase 1 trial testing the safety of an experimental nasal vaccine that may provide enhanced breadth of protection against emerging variants of SARS-CoV-2, the virus that causes COVID-19, is now enrolling healthy adults at three sites in the United States.

1 Jul 2024

Neanderthal child with Down syndrome reveals ancient caregiving practices

Research reveals that Neanderthals provided extensive caregiving, allowing a child with Down syndrome and congenital ear pathology to survive for at least six years, highlighting their complex social structures.

1 Jul 2024

Clinical trial seeks to evaluate safety of new EV-D68 treatment

The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enterovirus D68 (EV-D68), which can cause severe respiratory and neurological diseases such as acute flaccid myelitis (AFM) – similar to polio. Scientists are striving to better understand AFM, which has emerged in the United States with spikes in cases every other year, primarily in the late-summer months over the last decade.

28 Jun 2024

LJI study details measles virus neutralization

What happens when measles virus meets a human cell? The viral machinery unfolds in just the right way to reveal key pieces that let it fuse itself into the host cell membrane.

28 Jun 2024

Amorphous calcium phosphate drives aortic valve stiffening

The human body has sophisticated defenses against the deposition of calcium minerals that stiffen heart tissues, researchers at the University of Illinois Urbana-Champaign and collaborators at UCLA Health and the University of Texas at Austin found in a new study that provides the first detailed, step-by-step documentation of how calcification progresses.

27 Jun 2024

NIAID scientists discover probiotic treatment for eczema

NIAID research has led to the availability of a new over-the-counter topical eczema probiotic.

26 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Lenacapavir: A breakthrough in long-acting HIV prevention for cisgender women

The injectable antiretroviral drug lenacapavir was safe and 100% effective as long-acting HIV pre-exposure prophylaxis (PrEP) among cisgender women in a Phase 3 clinical trial, according to top-line findings released by Gilead Sciences, Inc., the study sponsor.

26 Jun 2024

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

Partners to host joint conference on ‘Protein Sciences in Drug Discovery’ in Cambridge, UK from 18–19 November 2024.

From ELRIG (UK) Ltd. 26 Jun 2024

Liquid core fibers offer long-term drug delivery in medical textiles

Treating a wound or an inflammation directly where it occurs has clear advantages: The active ingredient reaches its target immediately, and there are no negative side effects on uninvolved parts of the body.

26 Jun 2024

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides like strychnine and anticancer drugs such as vinblastine and minovincine.

24 Jun 2024

High-resolution structures of SSTR5 reveal key interactions with neuropeptide and drug agonists

Somatostatin receptors (SSTRs) constitute a crucial family of G protein-coupled receptors (GPCRs) that play pivotal roles in regulating hormone secretion and inhibiting tumor growth.

21 Jun 2024

Research finds microplastics in human penile tissue

The accumulation of microplastics in penile tissue to determine potential toxicity concerns.

21 Jun 2024

Antioxidants combat high-fat diet-induced female reproductive issues, study reveals

Researchers in Italy review how antioxidants from biological matrices can protect against reproductive issues caused by high-fat diets in women.

11 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024

Unveiling Pseudomonas aeruginosa's lung invasion tactics with human lung microtissues

How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen.

10 Jun 2024

Electron News and Research

Scientists map molecules within human brain for first time

Study reveals how DDM1 protein suppresses 'jumping genes' in plants

Cryo-EM reveals structural dynamics of RNAP-DNA interactions during transcription initiation

New study reveals how RNA polymerase opens the transcription bubble in real time

NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine

Neanderthal child with Down syndrome reveals ancient caregiving practices

Clinical trial seeks to evaluate safety of new EV-D68 treatment

LJI study details measles virus neutralization

Amorphous calcium phosphate drives aortic valve stiffening

NIAID scientists discover probiotic treatment for eczema

Novel approach can make many more bacteria amenable to genetic engineering

Lenacapavir: A breakthrough in long-acting HIV prevention for cisgender women

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

Liquid core fibers offer long-term drug delivery in medical textiles

Advances in Diels-Alder synthesis of hydrocarbazole compounds using lanthanide catalysts

High-resolution structures of SSTR5 reveal key interactions with neuropeptide and drug agonists

Research finds microplastics in human penile tissue

Antioxidants combat high-fat diet-induced female reproductive issues, study reveals

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

Unveiling Pseudomonas aeruginosa's lung invasion tactics with human lung microtissues

Accelerate Your Research: Harness the Power of 3D Models with Dispen3D

Exploring the benefits of miniaturizing NGS library preparation

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

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