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Austocystin D's anticancer efficacy linked to CYP2J2 enzyme activity

Austocystin D, a natural compound produced by fungi, has been recognized for its cytotoxic effects and anticancer activity in various cell types. It exhibits potent activity even in cells that express proteins associated with multidrug resistance, attracting significant global research interest.

27 Aug 2024

Exploring the health benefits and production challenges of alternative proteins

Researchers review the health benefits of alternative protein sources and the challenges associated with their production.

20 Aug 2024

Higher heme iron intake linked to increased risk of type 2 diabetes

Higher intake of heme iron, the type found in red meat and other animal products-;as opposed to non-heme iron, found mostly in plant-based foods-;was associated with a higher risk of developing type 2 diabetes (T2D) in a new study led by researchers at Harvard T.H. Chan School of Public Health.

13 Aug 2024

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

In a groundbreaking study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer's disease, and schizophrenia.

12 Aug 2024

EZH2's role in cancer progression and therapy explored

Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of the Polycomb-repressive complex 2 (PRC2), which plays a crucial role in transcriptional repression through the methylation of histone H3 on lysine 27 (H3K27me3).

9 Aug 2024

New strategy for mRNA nanocarriers using triphenyl phosphonium

Among the vastly different ways of tackling a disease, controlling the genetic expression of cells is undoubtedly one of the most powerful. Over the past few decades, scientists have come up with dozens of innovative strategies that involve using messenger RNA (mRNA) to 'force' cells to build specific proteins. These mRNA-based therapies have recently gained prominence as vaccines against infectious diseases like COVID-19. Additionally, they hold significant potential for treating cancer and genetic disorders.

23 Jul 2024

New insights into modified nucleoside synthesis

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system.

19 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

New study reveals rare genetic variants significantly increase atrial fibrillation risk

Researchers identified rare genetic variants that significantly increase the risk of atrial fibrillation, enhancing AF risk stratification by combining these with polygenic risk scores.

28 Jun 2024

Study reveals a key step to help the heart regenerate after myocardial infarction

A new study by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham (MGB) healthcare system, reveals an important step to help the human heart regenerate after myocardial infarction (MI).

10 Jun 2024

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

Cornell University scientists have designed a way to "cloak" proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.

28 May 2024

Researchers elucidate how gene mutation mechanism causes autism

Researchers show how mutations of gene transcription and chromatin regulation-related genes cause autism.

9 Apr 2024

Unlocking quinoa's power: Beyond nutrition to drug development

Existing data on the bioactive constituents of quinoa and their health benefits.

18 Mar 2024

Ketogenic diet boosts brain's natural calm to combat epilepsy

A study in Cell Discovery shows the ketogenic diet increases brain GABA levels and the GABA/glutamate ratio through β-hydroxybutyric acid, offering a potential mechanism for its effectiveness in reducing epilepsy seizures.

15 Feb 2024

Scientists pinpoint two cell-surface proteins that partner to spur cancer cell growth

Scientists at City of Hope®, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells' ability to cause disease. The study was published in Nature Structural & Molecular Biology today.

5 Feb 2024

Nutrigenomics paves the way for customized diets in lactose intolerance care

The current evidence on omics tools that allow for developing tailored nutrition strategies for individuals with lactose intolerance (LI).

24 Jan 2024

Study finds previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease

Researchers explored the effects of a small humanin-like peptide 2 (SHLP2) variant on mitochondrial function.

4 Jan 2024