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Enzymatic RNA synthesis paves the way for sustainable therapeutics

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and amyloidosis.

12 Jul 2024

FDA approved PDE4 inhibitor roflumilast for atopic dermatitis

On July 9th, 2024, the U.S. FDA approved Arcutis Biotherapeutics' ZORYVE® (roflumilast) for treating atopic dermatitis (AD), the most common type of eczema affecting millions in the U.S. This once-daily, steroid-free cream could become a new standard of care for AD.

From Sino Biological Inc. 12 Jul 2024

Innovative technique speeds up search for antimicrobial drug candidates

A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.

11 Jul 2024

How lipoproteins shape your metabolic health

Study provides a comprehensive review of the lipoprotein pathway and its impact on healthy metabolism, highlighting the roles of HDL, LDL, and other lipoproteins in cardiovascular health and disease.

11 Jul 2024

Kobe University unveils key protein variants in exercise and weight loss

Some people lose weight slower than others after workouts, and a Kobe University research team found a reason.

11 Jul 2024

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.

11 Jul 2024

Scientists discover a molecular defect that promotes pathologic immune response in lupus

Northwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

10 Jul 2024

Novel molecule could inform new therapies for stroke-related brain injury

A newly developed molecule, LK-2, could inform new therapies for stroke-related brain injury, finds scientists at The Hospital for Sick Children (SickKids).

10 Jul 2024

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network.

10 Jul 2024

World’s first map of human brain lipids created

Scientists have found that 93% of the lipids in brain tissue are distributed differently in the white and gray matter, the subcortex, the visual and motor cortices, and the prefrontal cortex, which is responsible for decision-making, social behavior, and other functions.

10 Jul 2024

Fungal endophytes: A promising frontier for breast cancer treatment

A recent study in Heliyon highlights the potential of fungal endophytes in developing novel anti-cancer agents, specifically targeting breast cancer therapy.

10 Jul 2024

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer

Researchers at the Garvan Institute of Medical Research have identified a potential new therapeutic target for pancreatic cancer, one of the most lethal cancer types with limited treatment options.

9 Jul 2024

New platform developed to probe the function of genes involved in metabolism

A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism -; the sum of all life-sustaining chemical reactions.

9 Jul 2024

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium.

9 Jul 2024

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

8 Jul 2024

Blocking IL-6 in the brain to treat cancer cachexia

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes-;like the body's immune response-;to grow and spread.

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Behind the lab doors: Colman Byrne on the crucial role of analytical services

In this interview, News-Medical talks to Mr. Byrne about the crucial role of analytical services.

From DSI, a PLG Company 8 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide.

4 Jul 2024

Molecule News and Research

Enzymatic RNA synthesis paves the way for sustainable therapeutics

FDA approved PDE4 inhibitor roflumilast for atopic dermatitis

Innovative technique speeds up search for antimicrobial drug candidates

How lipoproteins shape your metabolic health

Kobe University unveils key protein variants in exercise and weight loss

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

Scientists discover a molecular defect that promotes pathologic immune response in lupus

Novel molecule could inform new therapies for stroke-related brain injury

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

World’s first map of human brain lipids created

Fungal endophytes: A promising frontier for breast cancer treatment

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer

New platform developed to probe the function of genes involved in metabolism

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Blocking IL-6 in the brain to treat cancer cachexia

Small molecule discovery offers hope for treatment of Angelman syndrome

Behind the lab doors: Colman Byrne on the crucial role of analytical services

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

Accelerate Your Research: Harness the Power of 3D Models with Dispen3D

Exploring the benefits of miniaturizing NGS library preparation

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

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