| Phenotype | All individuals were BRCA1 carriers. BRCA1 pathogenic variants were categorized according to their known or predicted effect on protein function: “class I” included loss-of-function variants expected to yield unstable or no protein; “class II” included variants likely to produce stable mutant proteins. Pathology data were obtained from pathology reviews, medical, pathology or tumor registry records, or immunohistochemical staining of tissue microarrays. All cases were individuals with prostate cancer. |
| Sample Ancestry | European |
| Total number | 450 individuals |
| Detailed numbers |
70 cases (15.56%)
380 controls
100.0% Male samples
|
| Number of Cohort(s) | 31 |
| Cohort Short Name | Cohort Full Name | Previous/other/additional names (e.g. sub-cohorts) |
|---|---|---|
| BCFR | Breast Cancer Family Registry | — |
| BCFR-CA | Breast Cancer Family Registry Canada | — |
| BCFR-UT | Utah site of the Breast Cancer Family Registry | — |
| BFBOCC | Baltic Familial Breast and Ovarian Cancer Consortium | — |
| BRICOH | Beckman Research Institute of the City of Hope | — |
| CBCS | Carolina Breast Cancer Study | — |
| CNIO | Spanish National Cancer Centre | — |
| CONSIT_TEAM | CONsorzio Studi ITaliani sui Tumori Ereditari Alla Mammella | CONSIT TEAM |
| DEMOKRITOS | Hellenic Cooperative Oncology Group | — |
| DKFZ | Deutsches Krebsforschungszentrum (German Cancer Research Center) | — |
| EMBRACE | Epidemiological study of BRCA1 and BRCA2 mutation carriers | — |
| FCCC | Fox Chase Cancer Center | — |
| GC-HBOC | German Consortium for Hereditary Breast & Ovarian Cancer | — |
| GEMO | Genetic Modifiers of cancer risk in BRCA1/2 mutation carriers | — |
| HEBCS | Helsinki Breast Cancer Study | — |
| HUNBOCS | Molecular Genetic Studies of Breast and Ovarian Cancer in Hungary | — |
| HVH | Heart and Vascular Health Study | — |
| ICO | Institut Català d'Oncologia | — |
| IOVHBOCS | Instituto Oncologico Veneto Hereditary Breast and Ovarian Cancer Study | — |
| kConFab | Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer | — |
| MAYO | The Mayo Clinic study | MAYO clinic biobank |
| MSKCC | Memorial Sloan Kettering Cancer Center | — |
| MUV | Medical University of Vienna | — |
| NCI | National Cancer Institute | — |
| OCGN | Ontario Cancer Genetics Network | — |
| OSUCCG | Ohio State University Comprehensive Cancer Centre | — |
| OUH | Odense University Hospital | — |
| SWE-BRCA | Swedish Breast Cancer Study | SWEBCS |
| UPENN | University of Pennsylvania | — |
| UPITT | Cancer Family Registry, University of Pittsburg | — |
| VFCTG | Victorian Familial Cancer Trials Group | — |
Additional cases and controls were obtained from UCHICAGO