Version 1
: Received: 31 October 2017 / Approved: 31 October 2017 / Online: 31 October 2017 (15:29:45 CET)
How to cite:
Gutierrez-Castrellon, P.; Luna-Carrasco, J.; Anzo-Osorio, A.; Diaz Garcia, L.; Villalpando-carrion, S.; López-Velázquez, G.; Jiménez-Gutiérrez, C. Impact of Optimized Protein in Infant Formula on the Metabolic and Nutritional Health in Infants: Systematic Review with Meta-Analysis. Preprints2017, 2017100195. https://doi.org/10.20944/preprints201710.0195.v1
Gutierrez-Castrellon, P.; Luna-Carrasco, J.; Anzo-Osorio, A.; Diaz Garcia, L.; Villalpando-carrion, S.; López-Velázquez, G.; Jiménez-Gutiérrez, C. Impact of Optimized Protein in Infant Formula on the Metabolic and Nutritional Health in Infants: Systematic Review with Meta-Analysis. Preprints 2017, 2017100195. https://doi.org/10.20944/preprints201710.0195.v1
Gutierrez-Castrellon, P.; Luna-Carrasco, J.; Anzo-Osorio, A.; Diaz Garcia, L.; Villalpando-carrion, S.; López-Velázquez, G.; Jiménez-Gutiérrez, C. Impact of Optimized Protein in Infant Formula on the Metabolic and Nutritional Health in Infants: Systematic Review with Meta-Analysis. Preprints2017, 2017100195. https://doi.org/10.20944/preprints201710.0195.v1
APA Style
Gutierrez-Castrellon, P., Luna-Carrasco, J., Anzo-Osorio, A., Diaz Garcia, L., Villalpando-carrion, S., López-Velázquez, G., & Jiménez-Gutiérrez, C. (2017). Impact of Optimized Protein in Infant Formula on the Metabolic and Nutritional Health in Infants: Systematic Review with Meta-Analysis. Preprints. https://doi.org/10.20944/preprints201710.0195.v1
Chicago/Turabian Style
Gutierrez-Castrellon, P., Gabriel López-Velázquez and Carlos Jiménez-Gutiérrez. 2017 "Impact of Optimized Protein in Infant Formula on the Metabolic and Nutritional Health in Infants: Systematic Review with Meta-Analysis" Preprints. https://doi.org/10.20944/preprints201710.0195.v1
Abstract
Background. Increasing evidence demonstrate that concentration of protein in infant formula >1.9g/100Kcal with high levels of insulinogenic aminoacids is associated with accelerated weight gain, increased fat mass accumulation and risk of adiposity. Purpose of this study was to conduct a systematic review to determine the metabolic effects in infants feed with infant formula optimized in protein. Methods. Systematic review was conducted according PRISMA Statement. RCTs with one intervention group (infant formula with 1.6-1.9gr of protein/100Kcal) and at least one comparative control group (infant formula with >1.9gr of protein/100Kcal) were included. Standardized mean differences (SMD), through random model were calculated. Results. 15 RCT were included. Optimized protein in infant formula was associated with less gain of BMI at 24 months of follow-up (SMD -0.25, IC95% -0.36 to -0.13, p 0.01) and less fat mass accumulation (SMD -0.68, IC95% -0.98 to -0.37, p 0.01). Optimized protein was also associated to less gain of weight, weight/age Z-score, weight/length Z-score, BUN (mmol/dL) and IGF1 (ng/ml). No effect on length/age Z-score was observed. Conclusions. Robust evidence showed optimized protein (1.6gr/100Kcal to 1.9gr/100Kcal) in infant formula is associated with metabolic benefits in infants with less weight gain, BMI and fat mass accumulation.
Keywords
Optimized protein in formula, infants, obesity risk reduction
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.