Shikhaliev, K.; Sabynin, A.; Sekirin, V.; Krysin, M.; Zubkov, F.; Yankina, K. A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters. Molecules2017, 22, 2035.
Shikhaliev, K.; Sabynin, A.; Sekirin, V.; Krysin, M.; Zubkov, F.; Yankina, K. A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters. Molecules 2017, 22, 2035.
Shikhaliev, K.; Sabynin, A.; Sekirin, V.; Krysin, M.; Zubkov, F.; Yankina, K. A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters. Molecules2017, 22, 2035.
Shikhaliev, K.; Sabynin, A.; Sekirin, V.; Krysin, M.; Zubkov, F.; Yankina, K. A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters. Molecules 2017, 22, 2035.
Abstract
A new synthetic approach to polyfunctional hexahydropyrrolo[3,4-b]pyrroles was developed based on cyclization of N-arylbromomaleimides with aminocrotonic acid esters. A highly chemo- and stereoselective reaction is a Hantzsch-type domino process, involving the steps of initial nucleophilic C-addition or substitution and subsequent intramolecular nucleophilic addition without recyclyzation of imide cycle.
Chemistry and Materials Science, Organic Chemistry
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