Review
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Structure and Function of Multimeric G-quadruplexes
Version 1
: Received: 15 August 2019 / Approved: 16 August 2019 / Online: 16 August 2019 (07:57:25 CEST)
A peer-reviewed article of this Preprint also exists.
Kolesnikova, S.; Curtis, E.A. Structure and Function of Multimeric G-Quadruplexes. Molecules 2019, 24, 3074. Kolesnikova, S.; Curtis, E.A. Structure and Function of Multimeric G-Quadruplexes. Molecules 2019, 24, 3074.
Abstract
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles. G-quadruplexes are often studied as monomers but can also form a variety of higher-order structures. This increases the structural and functional diversity of G-quadruplexes, and recent evidence suggests that it could also be biologically important. In this review we describe the types of multimeric topologies adopted by G-quadruplexes and highlight what is known about their sequence requirements. We also summarize the limited information available about potential biological roles of multimeric G-quadruplexes and suggest new approaches that could facilitate future studies of these structures.
Keywords
G-quadruplex; dimer; tetramer; multimer; oligomer; telomere; promoter; R-loop; DNA:RNA hybrid
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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