Version 1
: Received: 17 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (05:33:03 CEST)
How to cite:
Jain, P.; Dorik, R.; Jain, M. Identification of Pharmacophoric Features and Novel Compounds for Inhibition of SARS-Cov-2 Main Protease. Preprints2020, 2020040329. https://doi.org/10.20944/preprints202004.0329.v1
Jain, P.; Dorik, R.; Jain, M. Identification of Pharmacophoric Features and Novel Compounds for Inhibition of SARS-Cov-2 Main Protease. Preprints 2020, 2020040329. https://doi.org/10.20944/preprints202004.0329.v1
Jain, P.; Dorik, R.; Jain, M. Identification of Pharmacophoric Features and Novel Compounds for Inhibition of SARS-Cov-2 Main Protease. Preprints2020, 2020040329. https://doi.org/10.20944/preprints202004.0329.v1
APA Style
Jain, P., Dorik, R., & Jain, M. (2020). Identification of Pharmacophoric Features and Novel Compounds for Inhibition of SARS-Cov-2 Main Protease. Preprints. https://doi.org/10.20944/preprints202004.0329.v1
Chicago/Turabian Style
Jain, P., Rupesh Dorik and Munendra Jain. 2020 "Identification of Pharmacophoric Features and Novel Compounds for Inhibition of SARS-Cov-2 Main Protease" Preprints. https://doi.org/10.20944/preprints202004.0329.v1
Abstract
A big race for the search for novel lead has begun due to the emergence of COVID-19 across the globe. More than 6,00,000 cases of afflicted patients worldwide has been reported till date with high mortality and morbidity. At present no approved drugs are known for COVID-19. Phylogenetic analysis present strong nucleotide sequence similarity of around 80% with SARS-CoV. Therefore, the drugs used for treating SARS-CoV and MERS are being used for SARS-CoV-2 also. Recently, the crystal structure of COVID-19 is reported and hence, we have used this tom predict the binding affinity with SARS-CoV-2-main protease and prepared a pharmacophore that may be used for future design of novel inhibitors.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.