Version 1
: Received: 5 May 2020 / Approved: 6 May 2020 / Online: 6 May 2020 (15:20:27 CEST)
Version 2
: Received: 13 January 2021 / Approved: 15 January 2021 / Online: 15 January 2021 (13:14:15 CET)
How to cite:
Moradi, J.; Moghoofei, M.; Doroudian, M.; Abiri, R. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia. Preprints2020, 2020050100
Moradi, J.; Moghoofei, M.; Doroudian, M.; Abiri, R. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia. Preprints 2020, 2020050100
Moradi, J.; Moghoofei, M.; Doroudian, M.; Abiri, R. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia. Preprints2020, 2020050100
APA Style
Moradi, J., Moghoofei, M., Doroudian, M., & Abiri, R. (2021). Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia. Preprints. https://doi.org/
Chicago/Turabian Style
Moradi, J., Mohammad Doroudian and Ramin Abiri. 2021 "Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia" Preprints. https://doi.org/
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the current coronavirus pandemic is an infectious disease that initially confirmed in China in late December 2019. In this study, we analyzed 131 complete sequences of SARS-CoV-2 from Asia. Our results show that there are fifteen major mutations in Asia which most of them are co-evolved. There werefive groups based on co-mutations which three of them resulted in clade G including (241C>T, 3037C>T, 14408C>T, and 23403A>G), (28881G>A, 28882G>A, 28883G>C and 23403A>G) and (25563G>T and 23403A>G).Co-mutations in (8782C>T and 28144T>C) and (1397G>A, 28688T>C, 29742G>T and 11083G>T) were clustered in clade S and a new clade outside of GISAID classification, respectively. Sequences with a mutation in 26144G>T had low variability without any co-mutation which formed clade V. In this study, we showed that Most of the circulated viruses in Asia collected in five co-mutation groups which may affect the transmissibility and vaccine designing strategies.
Keywords
SARS-CoV-2; Phylogenetics; Asia
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
15 January 2021
Commenter:
Jale Moradi
Commenter's Conflict of Interests:
Author
Comment:
We have added extra analysis details and discussed the results more in comparison to the previous submission. Also, we added some details to the end of the title demonstrating the time of the analysis.
Commenter: Jale Moradi
Commenter's Conflict of Interests: Author