Version 1
: Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (16:16:59 CEST)
Version 2
: Received: 18 September 2020 / Approved: 19 September 2020 / Online: 19 September 2020 (04:49:18 CEST)
Version 3
: Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (10:43:56 CEST)
Version 4
: Received: 1 December 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (11:45:50 CET)
Version 5
: Received: 11 March 2021 / Approved: 15 March 2021 / Online: 15 March 2021 (13:03:33 CET)
Gomes, I.; Karmirian, K.; Oliveira, J. T.; Pedrosa, C. da S. G.; Mendes, M. A.; Rosman, F. C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection of the Central Nervous System in a 14-Month-Old Child: A Case Report of a Complete Autopsy. The Lancet Regional Health - Americas, 2021, 2, 100046. https://doi.org/10.1016/j.lana.2021.100046.
Gomes, I.; Karmirian, K.; Oliveira, J. T.; Pedrosa, C. da S. G.; Mendes, M. A.; Rosman, F. C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection of the Central Nervous System in a 14-Month-Old Child: A Case Report of a Complete Autopsy. The Lancet Regional Health - Americas, 2021, 2, 100046. https://doi.org/10.1016/j.lana.2021.100046.
Gomes, I.; Karmirian, K.; Oliveira, J. T.; Pedrosa, C. da S. G.; Mendes, M. A.; Rosman, F. C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection of the Central Nervous System in a 14-Month-Old Child: A Case Report of a Complete Autopsy. The Lancet Regional Health - Americas, 2021, 2, 100046. https://doi.org/10.1016/j.lana.2021.100046.
Gomes, I.; Karmirian, K.; Oliveira, J. T.; Pedrosa, C. da S. G.; Mendes, M. A.; Rosman, F. C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection of the Central Nervous System in a 14-Month-Old Child: A Case Report of a Complete Autopsy. The Lancet Regional Health - Americas, 2021, 2, 100046. https://doi.org/10.1016/j.lana.2021.100046.
Abstract
Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis, meningitis and multiple organ damage related to thrombosis, a previous encephalopathy may have contributed to additional cerebral damage. SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.
Keywords
SARS-CoV-2; COVID-19; CNS; infant; Choroid plexus
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Stevens Rehen
Commenter's Conflict of Interests: Author