Version 1
: Received: 24 January 2021 / Approved: 25 January 2021 / Online: 25 January 2021 (10:32:38 CET)
How to cite:
Arena, F.; Pollini, S.; Rossolini, G. M.; Margaglione, M. Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic. Preprints2021, 2021010473. https://doi.org/10.20944/preprints202101.0473.v1
Arena, F.; Pollini, S.; Rossolini, G. M.; Margaglione, M. Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic. Preprints 2021, 2021010473. https://doi.org/10.20944/preprints202101.0473.v1
Arena, F.; Pollini, S.; Rossolini, G. M.; Margaglione, M. Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic. Preprints2021, 2021010473. https://doi.org/10.20944/preprints202101.0473.v1
APA Style
Arena, F., Pollini, S., Rossolini, G. M., & Margaglione, M. (2021). Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic. Preprints. https://doi.org/10.20944/preprints202101.0473.v1
Chicago/Turabian Style
Arena, F., Gian Maria Rossolini and Maurizio Margaglione. 2021 "Summarize of the Available Molecular Methods for Detection of Sars-Cov-2 During the Ongoing Pandemic" Preprints. https://doi.org/10.20944/preprints202101.0473.v1
Abstract
Starting from early 2020, the COVID-19 pandemic has caused a morbidity and mortality excess worldwide. Containment strategies rely firstly on rapid and sensitive laboratory diagnosis with molecular detection of the viral genome in respiratory samples being the gold standard. Reliability of diagnostic protocols could be affected by SARS-CoV-2 genetic variability. In fact, mutations occurring during SARS-CoV-2 genomic evolution can involve the regions targeted by the diagnostic probes. Following a review of the literature and an in silico analysis of the most recently described virus variants (including the UK B 1.1.7 and the South Africa 501Y.V2 variants), we conclude that the described genetic variability should have minimal or no effect on the sensitivity of existing diagnostic protocols for SARS-CoV-2 genome detection. However, given the continuous emergence of new variants, the situation should be monitored in the future, and protocols including multiple targets should be preferred.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.