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Version 1
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Oligodendroglial Energy Metabolism and (re) Myelination
Version 1
: Received: 10 February 2021 / Approved: 11 February 2021 / Online: 11 February 2021 (10:57:28 CET)
A peer-reviewed article of this Preprint also exists.
Tepavčević, V. Oligodendroglial Energy Metabolism and (re)Myelination. Life 2021, 11, 238. Tepavčević, V. Oligodendroglial Energy Metabolism and (re)Myelination. Life 2021, 11, 238.
Abstract
Central nervous system (CNS) myelin has a crucial role in accelerating the propagation of action potentials and providing trophic support to the axons. Defective myelination and lack of myelin regeneration following demyelination can both lead to axonal pathology and neurodegeneration. Energy deficit has been evoked as an important contributor to various CNS disorders, including multiple sclerosis (MS). This suggests that dysregulation of energy homeostasis in oligodendroglia may be an important contributor to myelin dysfunction and lack of repair observed in the disease. This article will focus on energy metabolism pathways in oligodendroglial cells and highlight differences dependent on the maturation stage of the cell. In addition, it will emphasize that the use of alternative energy sources by oligodendroglia may be required to save glucose for functions that cannot be fulfilled by other metabolites, thus ensuring sufficient energy input for both myelin synthesis and trophic support to the axons. Finally, it will point out that neuropathological findings in a subtype of MS lesions likely reflect defective oligodendroglial energy homeostasis in the disease.
Keywords
energy metabolism; oligodendrocyte; oligodendrocyte progenitor cell; myelin; remyelination; multiple sclerosis; glucose; ketone bodies; lactate; N-acetyl aspartate; demyelination
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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