Kikushima, K.; Koyama, H.; Kodama, K.; Dohi, T. Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives. Molecules2021, 26, 1365.
Kikushima, K.; Koyama, H.; Kodama, K.; Dohi, T. Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives. Molecules 2021, 26, 1365.
Kikushima, K.; Koyama, H.; Kodama, K.; Dohi, T. Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives. Molecules2021, 26, 1365.
Kikushima, K.; Koyama, H.; Kodama, K.; Dohi, T. Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives. Molecules 2021, 26, 1365.
Abstract
Nucleophilic aromatic substitution (SNAr) reactions can provide metal-free access to synthesize mono-substituted aromatic compounds. We have developed efficient SNAr conditions for p-selective substitution of polyfluoroarenes with phenothiazine in the presence of a mild base to afford the corresponding 10-phenylphenothiazine (PTH) derivatives. The resulting polyfluoroarene-bearing PTH derivatives were subjected to a second SNAr reaction to generate highly functionalized PTH derivatives with potential applicability as photocatalysts for the reduction of carbon–halogen bonds.
Chemistry and Materials Science, Analytical Chemistry
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