Version 1
: Received: 30 October 2022 / Approved: 1 November 2022 / Online: 1 November 2022 (01:10:43 CET)
Version 2
: Received: 10 November 2022 / Approved: 14 November 2022 / Online: 14 November 2022 (01:12:17 CET)
How to cite:
Banceu, C.; Harpa, M.; Deac, R.; Brinzaniuc, K.; Tilea, I.; Varga, A.; Szabo, D. A.; Banceu, D.; Cristutiu, D.; Stoica, A.; Oprean, M.; Suciu, H. A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease. Preprints2022, 2022110003. https://doi.org/10.20944/preprints202211.0003.v2
Banceu, C.; Harpa, M.; Deac, R.; Brinzaniuc, K.; Tilea, I.; Varga, A.; Szabo, D. A.; Banceu, D.; Cristutiu, D.; Stoica, A.; Oprean, M.; Suciu, H. A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease. Preprints 2022, 2022110003. https://doi.org/10.20944/preprints202211.0003.v2
Banceu, C.; Harpa, M.; Deac, R.; Brinzaniuc, K.; Tilea, I.; Varga, A.; Szabo, D. A.; Banceu, D.; Cristutiu, D.; Stoica, A.; Oprean, M.; Suciu, H. A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease. Preprints2022, 2022110003. https://doi.org/10.20944/preprints202211.0003.v2
APA Style
Banceu, C., Harpa, M., Deac, R., Brinzaniuc, K., Tilea, I., Varga, A., Szabo, D. A., Banceu, D., Cristutiu, D., Stoica, A., Oprean, M., & Suciu, H. (2022). A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease. Preprints. https://doi.org/10.20944/preprints202211.0003.v2
Chicago/Turabian Style
Banceu, C., Marvin Oprean and Horatiu Suciu. 2022 "A New Understanding of Serum Creatinine Levels as a Predictive Factor of Mortality Outcomes in Aortic Disease" Preprints. https://doi.org/10.20944/preprints202211.0003.v2
Abstract
Acute kidney injury (AKI) is a complication that can occur after cardiac surgery and requires ongoing research in light of the exponential expansion of technological advancements and knowledge in medicine. In this study, we aim to evaluate the outcomes of treated electives of emergency aortic disease with high serum creatinine levels (SCr). Methods: The cohort includes 183 patients, all of whom have an aortic disease and whose SCr levels were checked upon admission on the first day in the intensive care unit (ICU) and upon discharge from the hospital. We examined the correlation of SCr levels with in-hospital mortality and immediate mortality at least six months after discharge as well as with cross-clamp time and bypass time.Results: A high SCr level upon admission is a significant predictive factor of n-hospital mortality (p = 0.001) but not immediate mortality (p = 0.409). A statistically significant correlation was also observed between elevated SCr level on the first day of ICU and aortic disease (p = 0.041) but not immediate mortality (p = 0.119). We observed a significant correlation between aortic disease and in-hospital mortality (p < 0.001), but no correlation was found between high SCr level on the first day of ICU and immediate mortality (p = 0.119). The cross-clamp time is statistically significant correlated with elevated SCr level (p = 0.013) and in-hospital mortality (p = 0.001) but not immediate mortality (p = 0.847). Furthermore, the bypass time is negatively correlated with a high SCr level on the first day of ICU (p = 0.090), in-hospital mortality (p = 0.410), and immediate mortality (p = 0.625). We also found that aortic disease is not correlated with elevated creatinine levels at ICU discharge (p = 0.152) or long-term mortality (p = 0.106). Conclusions: Although this study only included a small portion of the elaborate aspects of surgical and medical management developed around cardiac patients who received invasive treatment, the conclusions reached are nevertheless clearly relevant, as evidenced by the significantly correlations uncovered. In order to manage AKI after AAS and improve the outcome, the SCr level could be used as a marker for renoprotective strategy. Moving forward, these results serve as a first step in motivating us to expand the range of our research, collect newly relevant data, and use it to benefit patients.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Banceu Cosmin
Commenter's Conflict of Interests: Author