Version 1
: Received: 3 November 2022 / Approved: 8 November 2022 / Online: 8 November 2022 (10:28:06 CET)
How to cite:
Ohe, M.; Haruki, S.; Yamamoto, J.; Seki, M.; Furuya, K. Successful Treatment With Minocycline and Saiko-Keishi-to for Covid-19-Associated CNS Lesion. Preprints2022, 2022110153. https://doi.org/10.20944/preprints202211.0153.v1
Ohe, M.; Haruki, S.; Yamamoto, J.; Seki, M.; Furuya, K. Successful Treatment With Minocycline and Saiko-Keishi-to for Covid-19-Associated CNS Lesion. Preprints 2022, 2022110153. https://doi.org/10.20944/preprints202211.0153.v1
Ohe, M.; Haruki, S.; Yamamoto, J.; Seki, M.; Furuya, K. Successful Treatment With Minocycline and Saiko-Keishi-to for Covid-19-Associated CNS Lesion. Preprints2022, 2022110153. https://doi.org/10.20944/preprints202211.0153.v1
APA Style
Ohe, M., Haruki, S., Yamamoto, J., Seki, M., & Furuya, K. (2022). Successful Treatment With Minocycline and Saiko-Keishi-to for Covid-19-Associated CNS Lesion. Preprints. https://doi.org/10.20944/preprints202211.0153.v1
Chicago/Turabian Style
Ohe, M., Masahide Seki and Ken Furuya. 2022 "Successful Treatment With Minocycline and Saiko-Keishi-to for Covid-19-Associated CNS Lesion" Preprints. https://doi.org/10.20944/preprints202211.0153.v1
Abstract
Neuropsychiatric manifestations of COVID-19 include delirium, general malaise, headache, and psychiatric symptoms. These manifestations are related to the neuroinflammatory response to viral antigens and proinflammatory mediators/immune cells. Tetracyclines, such as minocycline, have antibacterial and anti-inflammatory properties. Saiko-keishi-to, a traditional Japanese Kampo medicine, also has anti-inflammatory properties. Given the anti-inflammatory properties of minocycline and Saiko-keishi-to, we describe two cases of COVID-19 with prolonged headaches and general malaise successfully treated with these medications.
Keywords
COVID-19; minocycline; saiko-keishi-to
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.