Review
Version 1
Preserved in Portico This version is not peer-reviewed
P2x7 Receptor and Extracellular Vesicle Release
Version 1
: Received: 30 April 2023 / Approved: 2 May 2023 / Online: 2 May 2023 (03:54:14 CEST)
A peer-reviewed article of this Preprint also exists.
Golia, M.T.; Gabrielli, M.; Verderio, C. P2X7 Receptor and Extracellular Vesicle Release. Int. J. Mol. Sci. 2023, 24, 9805. Golia, M.T.; Gabrielli, M.; Verderio, C. P2X7 Receptor and Extracellular Vesicle Release. Int. J. Mol. Sci. 2023, 24, 9805.
Abstract
Extensive evidence indicates that activation of P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.
Keywords
P2X7 receptor; extracellular vesicles; inflammation; neurodegeneration
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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