Version 1
: Received: 27 April 2023 / Approved: 3 May 2023 / Online: 3 May 2023 (12:43:28 CEST)
How to cite:
Liu, M.-M.; Shang, H.; Feng, X.-L.; Qi, C.; Zhang, S.-E.; Sun, Y.-C.; Gou, C.-Y.; Sun, Y.-J.; Zhang, G.-L. Epididymis May Be More Important in Male Fertility than Our Cognition. Preprints2023, 2023050151. https://doi.org/10.20944/preprints202305.0151.v1
Liu, M.-M.; Shang, H.; Feng, X.-L.; Qi, C.; Zhang, S.-E.; Sun, Y.-C.; Gou, C.-Y.; Sun, Y.-J.; Zhang, G.-L. Epididymis May Be More Important in Male Fertility than Our Cognition. Preprints 2023, 2023050151. https://doi.org/10.20944/preprints202305.0151.v1
Liu, M.-M.; Shang, H.; Feng, X.-L.; Qi, C.; Zhang, S.-E.; Sun, Y.-C.; Gou, C.-Y.; Sun, Y.-J.; Zhang, G.-L. Epididymis May Be More Important in Male Fertility than Our Cognition. Preprints2023, 2023050151. https://doi.org/10.20944/preprints202305.0151.v1
APA Style
Liu, M. M., Shang, H., Feng, X. L., Qi, C., Zhang, S. E., Sun, Y. C., Gou, C. Y., Sun, Y. J., & Zhang, G. L. (2023). Epididymis May Be More Important in Male Fertility than Our Cognition. Preprints. https://doi.org/10.20944/preprints202305.0151.v1
Chicago/Turabian Style
Liu, M., Yu-Jiang Sun and Guo-Liang Zhang. 2023 "Epididymis May Be More Important in Male Fertility than Our Cognition" Preprints. https://doi.org/10.20944/preprints202305.0151.v1
Abstract
Sperm gain fertilization ability and forward movement characteristics during epididymal transport. Sperm maturation is inseparable from the processing of the epididymis. Compared with other reproductive organs, relatively little is known about the epididymis. However, with the development of molecular biology and the improvement of single-cell sequence technology, we gradually realized that we should re-examine the importance of the epididymis for sperm mat-uration and for the entire male reproductive system. Recently, epididymis related reports have tended to be more regionalized and more refined. We can understand cell distribution and gene expression from the perspective of a single cell. It has been reported that different regions of the epididymis have different functions and different cell compositions, which may be determined by gene expression. Here, we comprehensively reviewed the epididymal studies. From the ana-tomical structure of the epididymis to the division of its regions, we focused on the cell compo-sition and region-specific genes differentially expressed in the epididymis. The gene expression of the epididymis extends to a series of biological processes of sperm in the epididymal cavity, and the serious effects of epididymal diseases on reproduction are discussed. Therefore, the importance of the epididymis in male reproduction is emphasized. With the maturity of single-cell spatial transcriptomics, it is hoped that the technology can be applied to epididymal research and bring about the spatiotemporal landscape of the epididymis at the single-cell level.
Keywords
Epididymis; Regional; Single cell/Spatial Transcriptomics
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.