Review
Version 1
Preserved in Portico This version is not peer-reviewed
An Overview of Catalytic Carbonylative Double Cyclization Reactions
Version 1
: Received: 30 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (14:10:04 CEST)
A peer-reviewed article of this Preprint also exists.
Gabriele, B.; Mancuso, R.; Della Ca’, N.; Veltri, L.; Ziccarelli, I. An Overview of Catalytic Carbonylative Double Cyclization Reactions. Catalysts 2023, 13, 1025. Gabriele, B.; Mancuso, R.; Della Ca’, N.; Veltri, L.; Ziccarelli, I. An Overview of Catalytic Carbonylative Double Cyclization Reactions. Catalysts 2023, 13, 1025.
Abstract
This short review is aimed at giving an overview of catalytic carbonylative double cyclization reactions, which are processes in which suitable organic substrates and carbon monoxide are sequentially activated by a promoting catalyst to afford the formation of two new cycles with concomitant incorporation of carbon monoxide as a carbonyl function into the final product. Paradigmatic examples of this powerful synthetic methodology, which allows the one-step synthesis of complex molecular architectures from simple building blocks using the simplest and readily available C-1 unit (CO) are illustrated and discussed. The review is divided into five sections: 1) Introduction; 2) Functionalized Olefinic Substrates; 3) Functionalized Acetylenic Substrates; 4) Functionalized Halides; 5) Conclusions and Future Perspectives.
Keywords
carbonylation; cyclization; double cyclization; fused heterocycles; heterocyclization; heterocycles; homogeneous catalysis; metal-catalyzed reactions; palladium; polycyclic heterocycles
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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