Version 1
: Received: 8 June 2023 / Approved: 9 June 2023 / Online: 9 June 2023 (04:39:56 CEST)
How to cite:
Dumitru, R.; Grasu, M. C.; Iuhas, G.; Ispas, M. E.; Toma, M. G.; Lupescu, I. G. Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study. Preprints2023, 2023060668. https://doi.org/10.20944/preprints202306.0668.v1
Dumitru, R.; Grasu, M. C.; Iuhas, G.; Ispas, M. E.; Toma, M. G.; Lupescu, I. G. Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study. Preprints 2023, 2023060668. https://doi.org/10.20944/preprints202306.0668.v1
Dumitru, R.; Grasu, M. C.; Iuhas, G.; Ispas, M. E.; Toma, M. G.; Lupescu, I. G. Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study. Preprints2023, 2023060668. https://doi.org/10.20944/preprints202306.0668.v1
APA Style
Dumitru, R., Grasu, M. C., Iuhas, G., Ispas, M. E., Toma, M. G., & Lupescu, I. G. (2023). Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study. Preprints. https://doi.org/10.20944/preprints202306.0668.v1
Chicago/Turabian Style
Dumitru, R., Mihai Gheorghe Toma and Ioana Gabriela Lupescu. 2023 "Radiofrequency Ablation in Hepatocellular Carcinoma: Necrosis Volumetric Assessment as a Predictor for Local Tumour Progression, a Retrospective Study" Preprints. https://doi.org/10.20944/preprints202306.0668.v1
Abstract
(1) Background: Evaluating if necrosis volumetric assessment of pre-/post-RFA in HCC can be an accurate predictor of LTP (local tumor progression) and survival.; (2) Methods: Retrospective, descriptive and analytical study conducted between 01.01.2018 - 30.09.2021 in the Radiology and Medical Imaging Department of Fundeni Clinical Institute. 35 patients, each with one LI-RADS 4 or 5 treated lesion were eligible to be included. Volumetry was performed using OsiriX MD. Initial lesion volume, ideal necrosis volume (0,5-1 cm safety margin) and actual necrosis volume at 1 and 6 months post-procedure were performed; (3) Results: Results and discussions: Actual necrosis volume is influenced by several factors: lesion position, proximity to great vessels or other critical structures. The overall recurrence-free survival rate was similar to data in other studies (77% in the first year post-RFA). This study showed that having the actual necrosis volume at 1 month smaller than ideal necrosis volume is a good predictor for local tumor progression (p < 0,05); (4) Conclusions: Volumetric assessment of necrosis is easily attainable and can help improve prediction of local tumour progression.
Keywords
radiofrequency ablation; hepatocarcinoma; volumetry; local tumour progression.
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.