Tabriz, A.G.; Gonot-Munck, Q.; Baudoux, A.; Garg, V.; Farnish, R.; Katsamenis, O.L.; Hui, H.-W.; Boersen, N.; Roberts, S.; Jones, J.; Douroumis, D. 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering. Pharmaceutics2023, 15, 2230.
Tabriz, A.G.; Gonot-Munck, Q.; Baudoux, A.; Garg, V.; Farnish, R.; Katsamenis, O.L.; Hui, H.-W.; Boersen, N.; Roberts, S.; Jones, J.; Douroumis, D. 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering. Pharmaceutics 2023, 15, 2230.
Tabriz, A.G.; Gonot-Munck, Q.; Baudoux, A.; Garg, V.; Farnish, R.; Katsamenis, O.L.; Hui, H.-W.; Boersen, N.; Roberts, S.; Jones, J.; Douroumis, D. 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering. Pharmaceutics2023, 15, 2230.
Tabriz, A.G.; Gonot-Munck, Q.; Baudoux, A.; Garg, V.; Farnish, R.; Katsamenis, O.L.; Hui, H.-W.; Boersen, N.; Roberts, S.; Jones, J.; Douroumis, D. 3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering. Pharmaceutics 2023, 15, 2230.
Abstract
Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 laser for the manufacturing of carvedilol personalised dos-age forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25 and 12.5 mg. The tuning of the SLS processing parameter laser intensity, improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug re-leased. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO2 intensity affected the total tablet po-rosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.
Keywords
3D printing; selective laser sintering; personalised medicines; oral; carvedilol
Subject
Medicine and Pharmacology, Pharmacy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.