Giansante, V.; Stati, G.; Sancilio, S.; Guerra, E.; Alberti, S.; Di Pietro, R. The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci.2023, 24, 12633.
Giansante, V.; Stati, G.; Sancilio, S.; Guerra, E.; Alberti, S.; Di Pietro, R. The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2023, 24, 12633.
Giansante, V.; Stati, G.; Sancilio, S.; Guerra, E.; Alberti, S.; Di Pietro, R. The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci.2023, 24, 12633.
Giansante, V.; Stati, G.; Sancilio, S.; Guerra, E.; Alberti, S.; Di Pietro, R. The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma. Int. J. Mol. Sci. 2023, 24, 12633.
Abstract
Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has con-tinued to increase by about 1% each year in both men and women. Although the 5‐year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeutic strategies are urgently needed. Challenges in PC-targeted therapeutic strate-gies stem from the high PC heterogeneity and from the poorly understood interplay between cancer cells and the surrounding microenvironment. Signaling pathways that drive PC cell growth have been the subject of intense scrutiny and interest has been attracted by necroptosis, a distinct type of programmed cell death. In this review, we provide a historical background on necroptosis and a detailed analysis of the ongoing debate on the role of necroptosis in PC malignant progression.
Keywords
pancreatic cancer; necroptosis; tumor microenvironment; cell death
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.