Version 1
: Received: 30 September 2023 / Approved: 2 October 2023 / Online: 2 October 2023 (11:01:58 CEST)
How to cite:
De Melo, E. L.; Tavares, B. A. M.; Santos, A. V. T. D. L. T. D.; Ferreira, A. M.; Carvalho, H. D. O.; Castro, A. N.; Pereira, A. C. M.; Moreira, L. F.; Carvalho, J. C. T. Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints2023, 2023100051. https://doi.org/10.20944/preprints202310.0051.v1
De Melo, E. L.; Tavares, B. A. M.; Santos, A. V. T. D. L. T. D.; Ferreira, A. M.; Carvalho, H. D. O.; Castro, A. N.; Pereira, A. C. M.; Moreira, L. F.; Carvalho, J. C. T. Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints 2023, 2023100051. https://doi.org/10.20944/preprints202310.0051.v1
De Melo, E. L.; Tavares, B. A. M.; Santos, A. V. T. D. L. T. D.; Ferreira, A. M.; Carvalho, H. D. O.; Castro, A. N.; Pereira, A. C. M.; Moreira, L. F.; Carvalho, J. C. T. Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints2023, 2023100051. https://doi.org/10.20944/preprints202310.0051.v1
APA Style
De Melo, E. L., Tavares, B. A. M., Santos, A. V. T. D. L. T. D., Ferreira, A. M., Carvalho, H. D. O., Castro, A. N., Pereira, A. C. M., Moreira, L. F., & Carvalho, J. C. T. (2023). Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints. https://doi.org/10.20944/preprints202310.0051.v1
Chicago/Turabian Style
De Melo, E. L., Luiz Fernando Moreira and Jose Carlos Tavares Carvalho. 2023 "Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo" Preprints. https://doi.org/10.20944/preprints202310.0051.v1
Abstract
Angiogenesis is a process whereby new blood vessels are born from preexistent ones, which has a role in transporting oxygen and nutrients. On the other hand, inhibiting this process is a strategy used to treat some diseases, including cancers, diabetic retinopathy, and rheumatoid arthritis. This study investigates the effect of a new nutraceutical (Terasen®) on angiogenesis. Terasen® is made from a standardized extract of Euterpe oleraceae (Açaí), Myrciaria dubia (Camu-Camu), and purified oil of Bixa orellana (Annatto) and Astrocaryum aculeatum (Tucumã). The in vivo angiogenesis model used was the chorioallantoic membrane (CAM) from chicken embryos. The embryos were divided into seven groups: a vehicle control treated with ethanol solution (ETH), a naïve control treated only with saline solution (SOR), a positive control treated with dexamethasone (DEX), and four groups treated with Terasen® at different concentrations (0.5, 1, 2, and 3 mg/ml). The parameters assessed were the vessels’ area, length, and amount. The results show a statistically significant and concentration-dependent inhibition of angiogenesis caused by Terasen®. Our results suggest the nutraceutical has a high antiangiogenesis potential, possibly due to its bioactive compounds, including anthocyanins, quercetin, and tocotrienols.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.