Labib, M.E.; Perazzo, A.; Manganaro, J.; Tabani, Y.; Milleman, K.R.; Milleman, J.L.; Walsh, L.J. Clinical Assessment of Plaque Removal Using a Novel Dentifrice Containing Cellulose Microfibrils. Dent. J.2024, 12, 7.
Labib, M.E.; Perazzo, A.; Manganaro, J.; Tabani, Y.; Milleman, K.R.; Milleman, J.L.; Walsh, L.J. Clinical Assessment of Plaque Removal Using a Novel Dentifrice Containing Cellulose Microfibrils. Dent. J. 2024, 12, 7.
Labib, M.E.; Perazzo, A.; Manganaro, J.; Tabani, Y.; Milleman, K.R.; Milleman, J.L.; Walsh, L.J. Clinical Assessment of Plaque Removal Using a Novel Dentifrice Containing Cellulose Microfibrils. Dent. J.2024, 12, 7.
Labib, M.E.; Perazzo, A.; Manganaro, J.; Tabani, Y.; Milleman, K.R.; Milleman, J.L.; Walsh, L.J. Clinical Assessment of Plaque Removal Using a Novel Dentifrice Containing Cellulose Microfibrils. Dent. J. 2024, 12, 7.
Abstract
Dentifrice performance in the removal of dental plaque is influenced by the interactions of dentifrice components with tooth surfaces. This randomized controlled clinical study assessed the effectiveness and safety of a novel fluoride dentifrice formulation that included a micro-fibrillated cellulose network with entangled microcrystalline cellulose and silica particles (ProtegeraTM), and compared this to a positive control fluoride dentifrice (Crest Cavity Protection™). Whole mouth dental plaque levels in 82 healthy adults were measured after the first supervised use, and following a week of twice daily use at home. Overall, the novel dentifrice was at least three times more effective in whole mouth plaque reductions than the reference dentifrice (p < 0.001), with a 38.6% reduction on first use, a 30.9% reduction at day 7, and a 41.6% reduction from day 1 to day 7, compared to reductions of 12.0%, 9.6%, and 11.6% respectively for the positive control. No safety issues arose from the use of the novel dentifrice. These results indicate that including micro-fibrillated cellulose enhances plaque removal effectiveness, without causing adverse changes to oral soft tissues.
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