Shintakuya, R.; Uemura, K.; Sumiyoshi, T.; Okada, K.; Baba, K.; Harada, T.; Murakami, Y.; Serikawa, M.; Ishii, Y.; Arihiro, K.; Takahashi, S. Optimal Lymphadenectomy in Patients with Well-Differentiated Nonfunctioning Pancreatic Neuroendocrine Neoplasms. J. Clin. Med.2023, 12, 6778.
Shintakuya, R.; Uemura, K.; Sumiyoshi, T.; Okada, K.; Baba, K.; Harada, T.; Murakami, Y.; Serikawa, M.; Ishii, Y.; Arihiro, K.; Takahashi, S. Optimal Lymphadenectomy in Patients with Well-Differentiated Nonfunctioning Pancreatic Neuroendocrine Neoplasms. J. Clin. Med. 2023, 12, 6778.
Shintakuya, R.; Uemura, K.; Sumiyoshi, T.; Okada, K.; Baba, K.; Harada, T.; Murakami, Y.; Serikawa, M.; Ishii, Y.; Arihiro, K.; Takahashi, S. Optimal Lymphadenectomy in Patients with Well-Differentiated Nonfunctioning Pancreatic Neuroendocrine Neoplasms. J. Clin. Med.2023, 12, 6778.
Shintakuya, R.; Uemura, K.; Sumiyoshi, T.; Okada, K.; Baba, K.; Harada, T.; Murakami, Y.; Serikawa, M.; Ishii, Y.; Arihiro, K.; Takahashi, S. Optimal Lymphadenectomy in Patients with Well-Differentiated Nonfunctioning Pancreatic Neuroendocrine Neoplasms. J. Clin. Med. 2023, 12, 6778.
Abstract
This study aimed to evaluate the optimal extent of lymphadenectomy in patients with nonfunctioning pancreatic neuroendocrine neoplasms. We retrospectively analyzed the clinicopathological data of patients with nonfunctioning pancreatic neuroendocrine neoplasms who underwent surgical resection. We investigated the frequency of metastases at each lymph node station according to tumor location and analyzed the factors contributing to poor overall survival (OS) and disease-free survival (DFS). Overall, data of 84 patients were analyzed. For pancreatic head tumors, metastases at stations 8, 13, and 17 were found in one (3.1%), four (12.5%), and three (9.3%) patients, respectively. However, none of the other stations showed metastases. For pancreatic body and tail tumors, only metastases at station 11 were found in two (5.1%) patients. Additionally, multivariate DFS and OS analyses showed that lymph node metastasis was the only independent prognostic factor. Lymph node metastasis was found near the primary tumor and was the only independent factor of poor prognosis in patients with nonfunctioning pancreatic neuroendocrine neoplasms after undergoing curative surgery. Peri-pancreatic lymphadenectomy might be recommended for nonfunctioning pancreatic neuroendocrine neoplasms.
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